Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin | |
Wei W; Zeve D; Suh JM; Wang X; Du Y(杜洋)![]() ![]() | |
发表期刊 | Molecular and Cellular Biology
![]() |
2011-12 | |
卷号 | 31期号:23页码:4692 |
摘要 | Osteoclasts are bone-resorbing cells essential for skeletal development, homeostasis, and regeneration. They derive from hematopoietic progenitors in the monocyte/macrophage lineage and differentiate in response to RANKL. However, the precise nature of osteoclast progenitors is a longstanding and important question. Using inducible peroxisome proliferator-activated receptor γ (PPARγ)-tTA TRE-GFP (green fluorescent protein) reporter mice, we show that osteoclast progenitors reside specifically in the PPARγ-expressing hematopoietic bone marrow population and identify the quiescent PPARγ(+) cells as osteoclast progenitors. Importantly, two PPARγ-tTA TRE-Cre-controlled genetic models provide compelling functional evidence. First, Notch activation in PPARγ(+) cells causes high bone mass due to impaired osteoclast precursor proliferation. Second, selective ablation of PPARγ(+) cells by diphtheria toxin also causes high bone mass due to decreased osteoclast numbers. Furthermore, PPARγ(+) cells respond to both pathological and pharmacological resorption-enhancing stimuli. Mechanistically, PPARγ promotes osteoclast progenitors by activating GATA2 transcription. These findings not only identify the long-sought-after osteoclast progenitors but also establish unprecedented tools for their visualization, isolation, characterization, and genetic manipulation. |
关键词 | Peroxisome Proliferator-activated Receptor (Ppar) |
DOI | 10.1128/MCB.05979-11 |
收录类别 | SCI |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/20493 |
专题 | 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Wei W,Zeve D,Suh JM,et al. Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin[J]. Molecular and Cellular Biology,2011,31(23):4692. |
APA | Wei W.,Zeve D.,Suh JM.,Wang X.,Du Y.,...&Wan Y.(2011).Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin.Molecular and Cellular Biology,31(23),4692. |
MLA | Wei W,et al."Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin".Molecular and Cellular Biology 31.23(2011):4692. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
zmb4692.pdf(6967KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
查看访问统计 |
导出为Endnote文件 |
谷歌学术 |
谷歌学术中相似的文章 |
[Wei W]的文章 |
[Zeve D]的文章 |
[Suh JM]的文章 |
百度学术 |
百度学术中相似的文章 |
[Wei W]的文章 |
[Zeve D]的文章 |
[Suh JM]的文章 |
必应学术 |
必应学术中相似的文章 |
[Wei W]的文章 |
[Zeve D]的文章 |
[Suh JM]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论