Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd

doi:10.1155/2018/9321862

	Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd
	Ma, Xibo1 ; Jin, Yushen1 ; Wang, Yi1,2 ; Zhang, Shuai1,3 ; Peng, Dong 1; Yang, Xin1 ; Wei, Shoushui 3; Chai, Wei 2; Li, Xuejun 4; Tian, Jie 1
发表期刊	CONTRAST MEDIA & MOLECULAR IMAGING
	2018
期号	2018 页码:9321862
文章类型	Article
摘要	Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy. The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence. A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells. In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N, N', N, N'-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy. For subcutaneous tumor, multimodality molecular imaging including photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) and the related processing techniques were used to monitor the pharmacokinetics process of GO-AuNS-DOTA-Gd in order to determine the optimal time for treatment. For orthotopic tumor, MRI was used to delineate the tumor location and margin in vivo before treatment. Then handheld photoacoustic imaging system was used to determine the tumor location during the surgery and guided the photothermal therapy. The experiment result based on orthotopic tumor demonstrated that this synergistic method could effectively reduce tumor residual and satellite metastases by 85.71% compared with the routine photothermal method without handheld PAI guidance. These results indicate that this multimodality molecular imaging-guided photothermal therapy method is promising with a good prospect in clinical application.
关键词	Multimodality Molecular Imaging Tumor Border Delineation Photothermal Therapy Hepatocellular Carcinoma
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1155/2018/9321862
关键词[WOS]	IN-VIVO ; HEPATOCELLULAR-CARCINOMA ; CANCER ; TOMOGRAPHY ; SYSTEM
收录类别	SCI
语种	英语
项目资助者	National Key Research Program of China(2016YFA0100900 ; National Natural Science Foundation of China(81227901 ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences(YZ201457) ; Beijing Natural Science Foundation(7174314) ; 2016YFA0100902) ; 815270805 ; 61231004 ; 81471739 ; 81472594 ; 81770781)
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000432965400001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/21694
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China 3.Shandong Univ, Sch Control Sci & Engn, Inst Biomed Engn, Jinan 250061, Shandong, Peoples R China 4.Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
第一作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Ma, Xibo,Jin, Yushen,Wang, Yi,et al. Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd[J]. CONTRAST MEDIA & MOLECULAR IMAGING,2018(2018):9321862.
APA	Ma, Xibo.,Jin, Yushen.,Wang, Yi.,Zhang, Shuai.,Peng, Dong.,...&Tian, Jie.(2018).Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd.CONTRAST MEDIA & MOLECULAR IMAGING(2018),9321862.
MLA	Ma, Xibo,et al."Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd".CONTRAST MEDIA & MOLECULAR IMAGING .2018(2018):9321862.

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