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Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease | |
Sun, Yu1,2; Wang, Yafei1; Lu, Jiaming3; Liu, Rengyuan4; Schwarz, Christopher G.5; Zhao, Hui4; Zhang, Yue1; Xu, Lingyi1; Zhu, Bin3; Zhang, Bing3; Liu, Bing6; Wan, Suiren1; Xu, Yun4 | |
发表期刊 | ONCOTARGET |
2017-11-17 | |
卷号 | 8期号:58页码:99112-99124 |
文章类型 | Article |
摘要 | Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n= 33), mild cognitive impairment (MCI group, n= 31) and Alzheimer's disease (AD group, n= 27) was investigated in this study. The result shows significant differences of functional connectivity in 3 pairs of regions among NC group, MCI group and AD group: right perirhinal cortex with right hippocampus tail, left perirhinal cortex with right hippocampus tail, and right parahippocampal cortex with right hippocampus head. Clustering methods were used to classify NC group, MCI group and AD group (accuracy= 100%) as well as different subtypes of mild cognitive impairment patients based on functional alterations. Functional connectivity disrupted between perirhinal and parahippocampal cortex with hippocampal subfields, which may provide a better understanding of the neurodegenerative progress of MCI and AD. |
关键词 | Functional Connectivity Perirhinal Cortex Parahippocampal Cortex Ad Mci |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.18632/oncotarget.17944 |
关键词[WOS] | MEDIAL TEMPORAL-LOBE ; WORKING GROUP ; MEMORY ; PARCELLATION ; MODEL |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(81571040 ; Provincial Natural Science Foundation of Jiangsu(BK20131085) ; Provincial postdoctoral project(1501076A) ; project of the sixth peak of talented people(WSN-O50) ; key project of Nanjing Health Bureau(ZKX14027) ; Jiangsu Province Medical Key talent people ; 12th five years plan for China development(20112016 ; 81300925) ; RC2011013) |
WOS研究方向 | Oncology ; Cell Biology |
WOS类目 | Oncology ; Cell Biology |
WOS记录号 | WOS:000419392300114 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/21947 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Southeast Univ, Sch Biol Sci & Med Engn, Nanjing, Jiangsu, Peoples R China 2.Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England 3.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Radiol, Nanjing, Jiangsu, Peoples R China 4.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China 5.Mayo Clin & Mayo Fdn, Dept Radiol, Rochester, MN USA 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Yu,Wang, Yafei,Lu, Jiaming,et al. Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease[J]. ONCOTARGET,2017,8(58):99112-99124. |
APA | Sun, Yu.,Wang, Yafei.,Lu, Jiaming.,Liu, Rengyuan.,Schwarz, Christopher G..,...&Xu, Yun.(2017).Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease.ONCOTARGET,8(58),99112-99124. |
MLA | Sun, Yu,et al."Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease".ONCOTARGET 8.58(2017):99112-99124. |
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