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"All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration
Yan, Hao1,2; Shang, Wenting3; Sun, Xiaodan1; Zhao, Lingyun1; Wang, Jingyun1; Xiong, Zhiyuan1; Yuan, Jie1; Zhang, Ranran1; Huang, Qianli1; Wang, Kun3; Li, Baohua2; Tian, Jie3; Kang, Feiyu1,2; Feng, Si-Shen4
2018-02-28
发表期刊ADVANCED FUNCTIONAL MATERIALS
卷号28期号:9
文章类型Article
摘要Great efforts have been devoted so far to combine nano-magnetic hyperthermia and nano-photothermal therapy to achieve encouraging additive therapeutic performance in vitro and in vivo with limitation to direct intratumoral injection and no guidance of multimodality molecular imaging. In this study, a novel multifunctional theranostic nanoplatform (MNP@PES-Cy7/2-DG) consisting of magnetic nanoparticles (MNPs), poly(3,4-ethylenedioxythiophene): poly(4-styre-nesulfonate) (PES), Cyanine7 (Cy7), and 2-deoxyglucose (2-DG)-polyethylene glycol is developed. They are then applied to combined photo-magnetic hyperthermia therapy under intravenous administration that is simultaneously guided by trimodality molecular imaging. Remarkably, nanoparticles are found aggregated mainly in the cytoplasm of tumor cells in vitro and in vivo, and exhibit stealth-like behavior with a long second-phase blood circulation half-life of 20.38 +/- 4.18 h. Under the guidance of photoacoustic/near-infrared fluorescence/magnetic resonance trimodality imaging, tumors can be completely eliminated under intracellular photo-magnetic hyperthermia therapy with additive therapeutic effect due to precise hyperthermia. This study may promote a further exploration of such a platform for clinical applications.
关键词Breast Cancer Hyperthermia Molecular Imaging Nanomedicine Nanotheranostics
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201705710
关键词[WOS]IRON-OXIDE NANOPARTICLES ; PHOTOTHERMAL THERAPY ; PROSTATE-CANCER ; POLYPYRROLE NANOPARTICLES ; COMBINATION THERAPY ; DRUG CARRIER ; THERMOTHERAPY ; FEASIBILITY ; NANOCOMPOSITES ; EFFICIENCY
收录类别SCI
语种英语
项目资助者National Key Research and Development Program of China(2016YFB0700802) ; Inter governmental cooperation in science and technology(2016YFE0125300) ; NSFC(81172182 ; National Natural Science Foundation of China(81227901) ; 81671829)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000426154500018
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21953
专题中国科学院分子影像重点实验室
作者单位1.Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Sch Mat Sci & Engn, Beijing 100084, Peoples R China
2.Tsinghua Univ, Engn Lab Functionalized Carbon Mat, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore
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Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. "All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(9).
APA Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Jingyun.,...&Feng, Si-Shen.(2018)."All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration.ADVANCED FUNCTIONAL MATERIALS,28(9).
MLA Yan, Hao,et al.""All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration".ADVANCED FUNCTIONAL MATERIALS 28.9(2018).
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