Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia
Li, Yun1; Wang, Shengpei2,3; Pan, Chuxiong1; Xue, Fushan4,5; Xian, Junfang6; Huang, Yaqi7; Wang, Xiaoyi8; Li, Tianzuo1,9; He, Huiguang2
发表期刊PLOS ONE
2018-02-27
卷号13期号:2页码:1-19
文章类型Article
摘要

Background: The mechanism of general anesthesia (GA) has been explored for hundreds of years, but unclear. Previous studies indicated a possible correlation between NREM sleep and GA. The purpose of this study is to compare them by in vivo human brain function to probe the neuromechanism of consciousness, so as to find out a clue to GA mechanism.

Methods: 24 healthy participants were equally assigned to sleep or propofol sedation group by sleeping ability. EEG and Ramsay Sedation Scale were applied to determine sleep stage and sedation depth respectively. Resting-state functional magnetic resonance imaging (RS-fMRI) was acquired at each status. Regional homogeneity (ReHo) and seed-based whole brain functional connectivity maps (WB-FC maps) were compared.

Results: During sleep, ReHo primarily weakened on frontal lobe (especially preoptic area), but strengthened on brainstem. While during sedation, ReHo changed in various brain areas, including cingulate, precuneus, thalamus and cerebellum. Cingulate, fusiform and insula were concomitance of sleep and sedation. Comparing to sleep, FCs between the cortex and subcortical centers (centralized in cerebellum) were significantly attenuated under sedation. As sedation deepening, cerebellum-based FC maps were diminished, while thalamus- and brainstem-based FC maps were increased.

Conclusion: There're huge distinctions in human brain function between sleep and GA. Sleep mainly rely on brainstem and frontal lobe function, while sedation is prone to affect widespread functional network. The most significant differences exist in the precuneus and cingulate, which may play important roles in mechanisms of inducing unconciousness by anesthetics.

关键词Sleep, fMRI, General anesthesia
WOS标题词Science & Technology
DOI10.1371/journal.pone.0192358
关键词[WOS]CEREBRAL-BLOOD-FLOW ; POSITRON-EMISSION-TOMOGRAPHY ; PROPOFOL ANESTHESIA ; HUMANS ; CONNECTIVITY ; PRECUNEUS ; CINGULATE ; NEURONS ; INDEX ; RAT
收录类别SCI
语种英语
项目资助者National Science and Technology Pillar Program of China(2012BAI05B03) ; National Natural Science Foundation of China(81171422 ; Youth Innovation Promotion Association CAS ; 61271151 ; 91520202)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000426242400008
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21986
专题复杂系统管理与控制国家重点实验室_影像分析与机器视觉
作者单位1.Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
4.Chinese Acad Med Sci, Plast Surg Hosp, Dept Anesthesiol, Beijing, Peoples R China
5.Peking Union Med Coll, Beijing, Peoples R China
6.Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
7.Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
8.Beijing Tongren Hosp, Dept Laryngol, Sleep Med Ctr, Beijing, Peoples R China
9.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
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Li, Yun,Wang, Shengpei,Pan, Chuxiong,et al. Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia[J]. PLOS ONE,2018,13(2):1-19.
APA Li, Yun.,Wang, Shengpei.,Pan, Chuxiong.,Xue, Fushan.,Xian, Junfang.,...&He, Huiguang.(2018).Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia.PLOS ONE,13(2),1-19.
MLA Li, Yun,et al."Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia".PLOS ONE 13.2(2018):1-19.
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