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Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle
Du, Yang1,2,3; Fan, Kelong4; Zhang, Hejun5; Li, Li1; Wang, Peixia3,4; He, Jiuyang3,4; Ding, Shigang5; Yan, Xiyun3,4; Tian, Jie1,2,3
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
2018-10-01
Volume14Issue:7Pages:2259-2270
Corresponding AuthorDing, Shigang(dingshigang222@163.com) ; Yan, Xiyun(yanxy@sun5.ibp.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractOptical imaging technologies improve clinical diagnostic accuracy of early gastric cancer (EGC). However, there was a lack of imaging agents exhibiting molecular specificity for EGCs. Here, we employed the dye labeled human heavy-chain ferritin (HFn) as imaging nanoprobe, which recognizes tumor biomarker transferrin receptor 1 (TfR1), to enable specific EGC imaging using confocal laser endomicroscopy (CLE). TfR1 expression was initially examined in vitro in gastric tumor cells and in vivo through whole-body fluorescence and CLE imaging in tumor-bearing mice. Subsequently, dye labeled HFn was topically applied to resected human tissues for EGC detection. CLE analysis of TfR1-targeted fluorescence imaging allowed distinction of neoplastic from non-neoplastic tissues (P < 0.0001), and TfR1 expression level was found to correlate with EGC differentiation degrees (P < 0.0001). Notably, the CLE evaluation correlated well with the immunohistochemical findings (kappa-coefficient: 0.8023). Our HFn-nanoprobe-based CLE increases the accuracy of EGC detection and enables visualization of tumor margins and endoscopic resection. (c) 2018 Elsevier Inc. All rights reserved.
KeywordEarly gastric cancer Confocal laser endomicroscopy Human H-ferritin Molecular imaging Fluorescently labeled nanoprobe
DOI10.1016/j.nano.2018.07.007
WOS KeywordIN-VIVO ; CONFOCAL ENDOMICROSCOPY ; PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; RECEPTOR ; NANOCAGES ; TUMORS
Indexed BySCI
Language英语
Funding ProjectMinistry of Science and Technology of China[2016YFA0201404] ; Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571810] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81201186] ; National Natural Science Foundation of China[31530026] ; National Natural Science Foundation of China[81671810] ; Research and Development Program of China (973)[2015CB755500] ; Young Elite Scientist Sponsorship Program by CAST[2015QNRC001] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDB02060010] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDA09030306] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SMC013]
Funding OrganizationMinistry of Science and Technology of China ; National Natural Science Foundation of China ; Research and Development Program of China (973) ; Young Elite Scientist Sponsorship Program by CAST ; Strategic Priority Research Program from Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000446496900026
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/23047
Collection中国科学院分子影像重点实验室
Corresponding AuthorDing, Shigang; Yan, Xiyun; Tian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Beijing Key Lab Helicobacter Pylori Infect & Uppe, Dept Gastroenterol, Beijing, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Du, Yang,Fan, Kelong,Zhang, Hejun,et al. Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2018,14(7):2259-2270.
APA Du, Yang.,Fan, Kelong.,Zhang, Hejun.,Li, Li.,Wang, Peixia.,...&Tian, Jie.(2018).Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,14(7),2259-2270.
MLA Du, Yang,et al."Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14.7(2018):2259-2270.
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