Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression | |
Li Li; Du Yang; Xiang Dehui; Chen Liang; Shi Zhifeng; Tian Jie; Chen Xinjian | |
发表期刊 | Biomedical Optics Express |
2018-06-20 | |
卷号 | 9期号:7页码:3193-3207 |
摘要 | Currently, there is no effective way to assess the therapeutic response of temozolomide (TMZ) for the glioma. In this study, the human U87MG-fLuc glioma animal models were set up and the antitumor efficacy of TMZ was evaluated using bioluminescence imaging (BLI) and MRI. Then, bioluminescence tomography (BLT) was reconstructed using an adaptive sparsity matching pursuit (ASMP) algorithm. Second, the expression level of the MMP-750 probe was examined with or without TMZ treatment using FMI. Third, the expression of MMP2 and MMP3 was specifically examined after treatment. The results showed that TMZ effectively inhibited glioma growth. The targeted imaging of MMP-750 was decreased during the treatment of glioma with TMZ. Moreover, the MMP2 and MMP3 expression was found to correlate with the inhibition effect of TMZ. Our study indicated that the therapeutic effects of TMZ can be effectively evaluated at an early stage using molecular imaging, and MMP targeting the fluorescence probe could be utilized for the prediction and assessment of the therapeutic effects of TMZ. |
关键词 | Mdical And Biological Imaging, Tomographic Imaging, Spectroscopy, Fluorescence And Luminescence, Optical Diagnosis For Medicine |
收录类别 | SCI |
语种 | 英语 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/23181 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Du Yang; Tian Jie; Chen Xinjian |
推荐引用方式 GB/T 7714 | Li Li,Du Yang,Xiang Dehui,et al. Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression[J]. Biomedical Optics Express,2018,9(7):3193-3207. |
APA | Li Li.,Du Yang.,Xiang Dehui.,Chen Liang.,Shi Zhifeng.,...&Chen Xinjian.(2018).Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression.Biomedical Optics Express,9(7),3193-3207. |
MLA | Li Li,et al."Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression".Biomedical Optics Express 9.7(2018):3193-3207. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
LL_BOE_2018.pdf(4745KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论