中国科学院分子影像重点实验室知识库

Lymphovascular space invasion (LVSI) is an important determinant for selecting treatment plan in cervical cancer (CC). For CC patients without LVSI, conization is recommended; otherwise, if LVSI is observed, hysterectomy and pelvic lymph node dissection are required. Despite the importance, current identification of LVSI can only be obtained by pathological examination through invasive biopsy or after surgery. In this study, we provided a non-invasive and preoperative method to identify LVSI by radiomics analysis on T2-magnetic resonance image (MRI), aiming at assisting personalized treatment planning. We enrolled 120 CC patients with T2 image and clinical information, and allocated them into a training set (n = 80) and a testing set (n= 40) according to the diagnosis time. Afterwards, 839 image features were extracted to reflect the intensity, shape, and high-dimensional texture information of CC. Among the 839 radiomic features, 3 features were identified to be discriminative by Least absolute shrinkage and selection operator (Lasso)-Logistic regression. Finally, we built a support vector machine (SVM) to predict LVSI status by the 3 radiomic features. In the independent testing set, the radiomics model achieved area under the receiver operating characteristic curve (AUC) of 0.7356, classification accuracy of 0.7287. The radiomics signature showed significant difference between non-LVSI and LVSI patients (p<0.05). Furthermore, we compared the radiomics model with clinical model that uses clinical information, and the radiomics model showed significant improvement than clinical factors (AUC=0.5967 in the validation cohort for clinical model).