CASIA OpenIR
Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study
Fu, Sirui1,2; Wei, Jingwei2,3; Zhang, Jie4; Dong, Di2,3; Song, Jiangdian2,3; Li, Yong1; Duan, Chongyang5; Zhang, Shuaitong2,3; Li, Xiaoqun6; Gu, Dongsheng2,3; Chen, Xudong7; Hao, Xiaohan2,3; He, Xiaofeng8; Yan, Jianfeng9; Liu, Zhenyu2,3; Tian, Jie2,3,10; Lu, Ligong1
Source PublicationCLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
ISSN2155-384X
2019-08-01
Volume10Pages:12
Corresponding AuthorTian, Jie(tian@ieee.org) ; Lu, Ligong(llg0902@sina.com)
AbstractOBJECTIVES: Models should be developed to assist choice between liver resection (LR) and transarterial chemoembolization (TACE) for hepatocellular carcinoma. METHODS: After separating 520 cases from 5 hospitals into training (n = 302) and validation (n = 218) data sets, we weighted the cases to control baseline difference and ensured the causal effect between treatments (LR and TACE) and estimated progression-free survival (PFS) difference. A noninvasive PFS model was constructed with clinical factors, radiological characteristics, and radiomic features. We compared our model with other 4 state-of-the-art models. Finally, patients were classified into subgroups with and without significant PFS difference between treatments. RESULTS: Our model included treatments, age, sex, modified Barcelona Clinic Liver Cancer stage, fusion lesions, hepatocellular carcinoma capsule, and 3 radiomic features, with good discrimination and calibrations (area under the curve for 3-year PFS was 0.80 in the training data set and 0.75 in the validation data set; similar results were achieved in 1- and 2-year PFS). The model had better accuracy than the other 4 models. A nomogram was built, with different scores assigned for LR and TACE. Separated by the threshold of score difference between treatments, for some patients, LR provided longer PFS and might be the better option (training: hazard ratio [HR] = 0.50, P= 0.014; validation: HR = 0.52, P= 0.026); in the others, LR provided similar PFS with TACE (training: HR = 0.84, P = 0.388; validation: HR = 1.14, P = 0.614). TACE may be better because it was less invasive. DISCUSSION: We propose an individualized model predicting PFS difference between LR and TACE to assist in the optimal treatment choice.
DOI10.14309/ctg.0000000000000070
WOS KeywordRADIOFREQUENCY ABLATION ; SURGICAL RESECTION ; SURVIVAL ; SORAFENIB ; OUTCOMES ; UPDATE
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFC1308701] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2016CZYD0001] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501549] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-SW-STS-160] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201502] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Youth Innovation Promotion Association CAS
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences ; Instrument Developing Project of the Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Youth Innovation Promotion Association CAS
WOS Research AreaGastroenterology & Hepatology
WOS SubjectGastroenterology & Hepatology
WOS IDWOS:000487054100001
PublisherLIPPINCOTT WILLIAMS & WILKINS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/27005
Collection中国科学院自动化研究所
Corresponding AuthorTian, Jie; Lu, Ligong
Affiliation1.Jinan Univ, Zhuhai Intervent Med Ctr, Zhuhai Precis Med Ctr, Zhuhai Peoples Hosp, Zhuhai, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Jinan Univ, Dept Radiol, Zhuhai Peoples Hosp, Zhuhai Hosp, Zhuhai, Peoples R China
5.Southern Med Univ, Dept Biostat, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China
6.Zhongshan City Peoples Hosp, Dept Intervent Treatment, Zhongshan, Peoples R China
7.Shenzhen Peoples Hosp, Dept Radiol, Shenzhen, Peoples R China
8.Southern Med Univ, Intervent Diag & Treatment Dept, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
9.Yangiang Peoples Hosp, Dept Radiol, Yangjiang, Peoples R China
10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Fu, Sirui,Wei, Jingwei,Zhang, Jie,et al. Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study[J]. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY,2019,10:12.
APA Fu, Sirui.,Wei, Jingwei.,Zhang, Jie.,Dong, Di.,Song, Jiangdian.,...&Lu, Ligong.(2019).Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study.CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY,10,12.
MLA Fu, Sirui,et al."Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study".CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY 10(2019):12.
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