A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial

doi:10.1007/s00464-019-07290-z

	A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial
	He, Kunshan 1,2; Hong, Xiaopeng 1; Chi, Chongwei3 ; Cai, Chaonong 1; Wang, Kun3 ; Li, Peiping 1; Liu, Xialei 1; Li, Jian 1; Shan, Hong 1; Tian, Jie 2,3
发表期刊	SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
ISSN	0930-2794
	2020-02-04
页码	8
通讯作者	Li, Jian(lijian5@mail.sysu.edu.cn) ; Shan, Hong(shanhong@mail.sysu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Background Hepatectomy is a definitive treatment for hepatolithiasis because it simultaneously removes intrahepatic duct (IHD) stones and biliary tract strictures together with the involved liver region en bloc. Unlike cystic or solid liver tumors, hepatolithiasis is usually associated with alterations of anatomical structures and perihepatic adhesions because of chronic recurrent inflammation. This complicates identification of the target hepatic region and location of biliary strictures. Methods To determine the efficacy of near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG), we performed a comparative trial and developed a white-light and near-infrared dual-channel image-guided device (DPM-I) for both open and endoscopic surgery. Forty-four eligible patients were randomly assigned to Group A (NIRF imaging) or Group B (traditional hepatectomy). We injected ICG via peripheral veins for patients in Group A. Results The NIRF imaging method was associated with less blood loss (OR 1.004, 95% CI 0.999-1.010; P = 0.016), briefer hospitalization (OR 1.336, 95% CI 1.016-1.756; P = 0.001), lower rates of margins with dilated bile ducts (OR 1.278, 95% CI 1.030-1.585; P = 0.023), lower postoperative white blood cell counts (OR 1.262, 95% CI 0.931-1.712; P = 0.038), lower procalcitonin levels (OR 1.316, 95% CI 1.020-1.513; P = 0.002), and lower alanine aminotransferase levels (OR 1.013, 95% CI 1.003-1.023; P = 0.002) compared with traditional hepatectomy. Conclusions These data demonstrate the efficacy of NIRF imaging with ICG using DPM-I for treating hepatolithiasis.
关键词	Near-infrared fluorescence Fluorescence image-guided hepatectomy Hepatolithiasis Indocyanine green Intraoperative imaging
DOI	10.1007/s00464-019-07290-z
关键词[WOS]	INDOCYANINE GREEN FLUORESCENCE ; LYMPH-NODE BIOPSY ; LAPAROSCOPIC APPROACH ; BREAST-CANCER ; RESECTION ; LITHOTOMY ; SURGERY
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of the People's Republic of China (MOST)[2017YFA0205200] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2017YFA0700401] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2016YFA0100902] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2019YFC0120800] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[81971773] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[QYZDJ-SSW-JSC005] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[KFJ-STS-ZDTP-059] ; Natural Science Foundation of Guangdong Province of China[2018A0303130292] ; Natural Science Foundation of Guangdong Province of China[2019A1515011356] ; Project of Administration of Traditional Chinese Medicine of Guangdong Province of China[20181062] ; China Postdoctoral Science Foundation[2019M660409] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2017YFA0205200] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2017YFA0700401] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2016YFA0100902] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2019YFC0120800] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[81971773] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[QYZDJ-SSW-JSC005] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[KFJ-STS-ZDTP-059] ; Natural Science Foundation of Guangdong Province of China[2018A0303130292] ; Natural Science Foundation of Guangdong Province of China[2019A1515011356] ; Project of Administration of Traditional Chinese Medicine of Guangdong Province of China[20181062] ; China Postdoctoral Science Foundation[2019M660409]
项目资助者	Ministry of Science and Technology of the People's Republic of China (MOST) ; National Natural Science Foundation of China (NSFC) ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS) ; Natural Science Foundation of Guangdong Province of China ; Project of Administration of Traditional Chinese Medicine of Guangdong Province of China ; China Postdoctoral Science Foundation
WOS研究方向	Surgery
WOS类目	Surgery
WOS记录号	WOS:000511080200001
出版者	SPRINGER
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/28617
专题	中国科学院分子影像重点实验室
通讯作者	Li, Jian; Shan, Hong; Tian, Jie
作者单位	1.Sun Yat Sen Univ, Affiliated Hosp 5, Zhuhai, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	He, Kunshan,Hong, Xiaopeng,Chi, Chongwei,et al. A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial[J]. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES,2020:8.
APA	He, Kunshan.,Hong, Xiaopeng.,Chi, Chongwei.,Cai, Chaonong.,Wang, Kun.,...&Tian, Jie.(2020).A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial.SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES,8.
MLA	He, Kunshan,et al."A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial".SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2020):8.