Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites

doi:10.1093/jrr/rrz033

CASIA OpenIR

	Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites
	Li, Jiaqi 1; Zhang, Xile 1; Li, Jun 1; Jiang, Rongtao 2,3; Sui, Jing 2,3; Chan, Maria F.4; Yang, Ruijie 1
发表期刊	JOURNAL OF RADIATION RESEARCH
ISSN	0449-3060
	2019-09-01
卷号	60 期号:5 页码:603-611
通讯作者	Chan, Maria F.(chanm@mskcc.org) ; Yang, Ruijie(ruijyang@yahoo.com)
摘要	This study aimed to investigate the impact of delivery characteristics on the dose delivery accuracy of volumetric modulated arc therapy (VMAT) for different treatment sites. The pretreatment quality assurance (QA) results of 344 VMAT patients diagnosed with gynecological (GYN), head and neck (H&N), rectal or prostate cancer were randomly chosen in this study. Ten metrics reflecting VMAT delivery characteristics were extracted from the QA plans. Compared with GYN and rectal plans, H&N and prostate plans had higher aperture complexity and monitor units (MU), and smaller aperture area. Prostate plans had the smallest aperture area and lowest leaf speed compared with other plans (P < 0.001). No differences in gantry speed were found among the four sites. The gamma passing rates (GPRs) of GYN, rectal and H&N plans were inversely associated with union aperture area (UAA) and leaf speed (Pearson's r: -0.39 to -0.68). GPRs of prostate plans were inversely correlated with aperture complexity, MU and small aperture score (SAS) (absolute Pearson's r: 0.34 to 0.49). Significant differences in GPR between high SAS and low SAS subgroups were found only when leaf speed was <0.42 cm s(-1) (P < 0.001). No association of GPR with gantry speed was found in four sites. Leaf speed was more strongly associated with UAA. Aperture complexity and MU were more strongly associated with SAS. VMAT plans from different sites have distinct delivery characteristics. Affecting dose delivery accuracy, leaf speed is the key factor for GYN, rectal and H&N plans, while aperture complexity, MU and small apertures have a higher influence on prostate plans.
关键词	complexity metrics volumetric modulated arc therapy quality assurance gamma passing rate
DOI	10.1093/jrr/rrz033
关键词[WOS]	RADIATION-THERAPY ; QUALITY-ASSURANCE ; PLAN QUALITY ; IMRT ; QA ; COMPLEXITY ; RADIOTHERAPY ; ERRORS ; VERIFICATION ; VALIDATION
收录类别	SCI
语种	英语
资助项目	National Cancer Institute at National Institutes of Health[CA008748] ; Interdisciplinary Medicine Seed Fund of Peking University[BMU20160585] ; National natural Science Foundation of China[81071237] ; National Natural Science Foundation of China[81071237] ; Interdisciplinary Medicine Seed Fund of Peking University[BMU20160585] ; National Cancer Institute at National Institutes of Health[CA008748]
项目资助者	National Natural Science Foundation of China ; Interdisciplinary Medicine Seed Fund of Peking University ; National Cancer Institute at National Institutes of Health
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Oncology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Biology ; Oncology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000493497700007
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/28779
通讯作者	Chan, Maria F.; Yang, Ruijie
作者单位	1.Peking Univ Third Hosp, Dept Radiat Oncol, 49 North Garden Rd, Beijing, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 4.Mem Sloan Kettering Canc Ctr, Med Phys Dept, 1275 York Ave, New York, NY 10021 USA
推荐引用方式 GB/T 7714	Li, Jiaqi,Zhang, Xile,Li, Jun,et al. Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites[J]. JOURNAL OF RADIATION RESEARCH,2019,60(5):603-611.
APA	Li, Jiaqi.,Zhang, Xile.,Li, Jun.,Jiang, Rongtao.,Sui, Jing.,...&Yang, Ruijie.(2019).Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites.JOURNAL OF RADIATION RESEARCH,60(5),603-611.
MLA	Li, Jiaqi,et al."Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites".JOURNAL OF RADIATION RESEARCH 60.5(2019):603-611.