A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer

doi:10.1002/jbio.201960152

	A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer
	Zhang, Zeyu1,2 ; Qu, Yawei 3,4; Cao, Yu 5; Shi, Xiaojing2,6 ; Guo, Hongbo 7; Zhang, Xiaojun 8; Zheng, Sheng 3; Liu, Haifeng 3; Hu, Zhenhua2,6 ; Tian, Jie 1,2,6,9
发表期刊	JOURNAL OF BIOPHOTONICS
ISSN	1864-063X
	2019-12-16
页码	11
通讯作者	Liu, Haifeng(haifengliu333@163.com) ; Hu, Zhenhua() ; Tian, Jie(tian@ieee.org)
摘要	Intraoperative Cerenkov luminescence imaging (CLI) can effectively improve the performance of tumor surgery. Nevertheless, the existing approaches are still unsatisfying to the clinical demands of open surgery. This study develops a novel intraoperative in vivo CLI approach to investigate the potential and value of Cerenkov luminescence (CL) image-guided surgery. A system characterized with high sensitivity (19.61 kBq mL(-1 18)F-FDG) and desirable spatial resolution (88.34 mu m) is developed. CL image-guided surgery is performed on colorectal cancer (CRC) models of mice and swine. Tumor surgery is guided by the static CL images, and the resection quality is evaluated quantitatively and contrasted with other imaging modalities exemplified by bioluminescence imaging (BLI). The in vivo results demonstrated the effectiveness of the proposed intraoperative CLI approach for removing primary and metastatic CRC. Safety of performing in vivo CL image-guided surgery is verified as well through radiation measurements of related staffs. Overall, the developed intraoperative in vivo CLI approach can efficiently improve the cancer treatment.
关键词	Cerenkov luminescence imaging colorectal cancer image-guided surgery in vivo
DOI	10.1002/jbio.201960152
关键词[WOS]	SYSTEM ; FEASIBILITY ; SENSITIVITY ; RESOLUTION ; ENDOSCOPY ; RADIATION ; POWER
收录类别	SCI
语种	英语
资助项目	Institute of Automation, Chinese Academy of Sciences ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81671759] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61622117] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; Chinese Academy of Sciences[YZ201672] ; Chinese Academy of Sciences[GJJSTD20170004] ; Beijing Nova Program[Z181100006218046] ; Beijing Nova Program[Z181100006218046] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YZ201672] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671759] ; National Natural Science Foundation of China[81930053] ; Institute of Automation, Chinese Academy of Sciences
项目资助者	Beijing Nova Program ; Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Institute of Automation, Chinese Academy of Sciences
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Optics
WOS类目	Biochemical Research Methods ; Biophysics ; Optics
WOS记录号	WOS:000502795400001
出版者	WILEY-V C H VERLAG GMBH
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/29422
专题	中国科学院分子影像重点实验室
通讯作者	Liu, Haifeng; Hu, Zhenhua; Tian, Jie
作者单位	1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging,CAS Key Lab Mol Imagi, Beijing, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Gastroenterol, 69 Yongding Rd, Beijing, Peoples R China 4.Harbin Inst Technol, Dept Control Sci & Engn, Harbin, Heilongjiang, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Anorectal, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Northwest Univ, Sch Informat Sci & Technol, Xian, Shaanxi, Peoples R China 8.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China 9.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang, Zeyu,Qu, Yawei,Cao, Yu,et al. A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer[J]. JOURNAL OF BIOPHOTONICS,2019:11.
APA	Zhang, Zeyu.,Qu, Yawei.,Cao, Yu.,Shi, Xiaojing.,Guo, Hongbo.,...&Tian, Jie.(2019).A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer.JOURNAL OF BIOPHOTONICS,11.
MLA	Zhang, Zeyu,et al."A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer".JOURNAL OF BIOPHOTONICS (2019):11.