CASIA OpenIR  > 中国科学院分子影像重点实验室
A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer
Zhang, Zeyu1,2; Qu, Yawei3,4; Cao, Yu5; Shi, Xiaojing2,6; Guo, Hongbo7; Zhang, Xiaojun8; Zheng, Sheng3; Liu, Haifeng3; Hu, Zhenhua2,6; Tian, Jie1,2,6,9
Source PublicationJOURNAL OF BIOPHOTONICS
ISSN1864-063X
2019-12-16
Pages11
Corresponding AuthorLiu, Haifeng(haifengliu333@163.com) ; Hu, Zhenhua() ; Tian, Jie(tian@ieee.org)
AbstractIntraoperative Cerenkov luminescence imaging (CLI) can effectively improve the performance of tumor surgery. Nevertheless, the existing approaches are still unsatisfying to the clinical demands of open surgery. This study develops a novel intraoperative in vivo CLI approach to investigate the potential and value of Cerenkov luminescence (CL) image-guided surgery. A system characterized with high sensitivity (19.61 kBq mL(-1 18)F-FDG) and desirable spatial resolution (88.34 mu m) is developed. CL image-guided surgery is performed on colorectal cancer (CRC) models of mice and swine. Tumor surgery is guided by the static CL images, and the resection quality is evaluated quantitatively and contrasted with other imaging modalities exemplified by bioluminescence imaging (BLI). The in vivo results demonstrated the effectiveness of the proposed intraoperative CLI approach for removing primary and metastatic CRC. Safety of performing in vivo CL image-guided surgery is verified as well through radiation measurements of related staffs. Overall, the developed intraoperative in vivo CLI approach can efficiently improve the cancer treatment.
KeywordCerenkov luminescence imaging colorectal cancer image-guided surgery in vivo
DOI10.1002/jbio.201960152
WOS KeywordSYSTEM ; FEASIBILITY ; SENSITIVITY ; RESOLUTION ; ENDOSCOPY ; RADIATION ; POWER
Indexed BySCI
Language英语
Funding ProjectBeijing Nova Program[Z181100006218046] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YZ201672] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671759] ; National Natural Science Foundation of China[81930053] ; Institute of Automation, Chinese Academy of Sciences ; Beijing Nova Program[Z181100006218046] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YZ201672] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671759] ; National Natural Science Foundation of China[81930053] ; Institute of Automation, Chinese Academy of Sciences
Funding OrganizationBeijing Nova Program ; Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Institute of Automation, Chinese Academy of Sciences
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Optics
WOS SubjectBiochemical Research Methods ; Biophysics ; Optics
WOS IDWOS:000502795400001
PublisherWILEY-V C H VERLAG GMBH
Sub direction classification医学影像处理与分析
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/29422
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiu, Haifeng; Hu, Zhenhua; Tian, Jie
Affiliation1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging,CAS Key Lab Mol Imagi, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Gastroenterol, 69 Yongding Rd, Beijing, Peoples R China
4.Harbin Inst Technol, Dept Control Sci & Engn, Harbin, Heilongjiang, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Anorectal, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Northwest Univ, Sch Informat Sci & Technol, Xian, Shaanxi, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China
9.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Zeyu,Qu, Yawei,Cao, Yu,et al. A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer[J]. JOURNAL OF BIOPHOTONICS,2019:11.
APA Zhang, Zeyu.,Qu, Yawei.,Cao, Yu.,Shi, Xiaojing.,Guo, Hongbo.,...&Tian, Jie.(2019).A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer.JOURNAL OF BIOPHOTONICS,11.
MLA Zhang, Zeyu,et al."A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer".JOURNAL OF BIOPHOTONICS (2019):11.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Zeyu]'s Articles
[Qu, Yawei]'s Articles
[Cao, Yu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Zeyu]'s Articles
[Qu, Yawei]'s Articles
[Cao, Yu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Zeyu]'s Articles
[Qu, Yawei]'s Articles
[Cao, Yu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.