Abnormal Diffusion of Cerebral White Matter in Early Blindness

	Abnormal Diffusion of Cerebral White Matter in Early Blindness
	Shu, Ni 1; Li, Jun 1; Li, Kuncheng 2; Yu, Chunshui 2; Jiang, Tianzi1
发表期刊	HUMAN BRAIN MAPPING
	2009
卷号	30 期号:1 页码:220-227
文章类型	Article
摘要	Early visual deprivation may lead to both abnormal and plastic changes in the visual and other systems of the brain. Such secondary changes in the gray matter of the early blind have been well studied, but not so well in the cerebral white matter whose subtle changes may be revealed by diffusion tensor imaging. The first purpose of this study is to explore the possible changed white matter regions of the early blind in whole brain manners, using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS) methods. The second purpose is to investigate the changes of diffusion eigenvalues in the abnormal white matter fiber tracts using tractography based group mapping analysis. From VBA of fractional anisotropy (FA) images, the significant changed white matter regions were the geniculocalcarine tract (GCT) and its adjacent regions. This finding was validated by TBSS method. Then we studied the changes of mean diffusivity (MD), FA, primary (lambda(1)) and transverse diffusivities (lambda(23)) in the GCT using tractography based group mapping analysis. We found the early blind had significantly lower FA (P < 0.0001), higher MD (P = 0.001) and lambda(23) (P < 0.0001) in the GCT. This pattern of diffusion changes is similar to findings seen in immaturity or axonal degeneration. Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind. Ham Brain Mapp 30:220-227, 2009. (c) 2007 Wiley-Liss, Inc.
关键词	Early Blind Diffusion Tensor Imaging Tractography Visual System
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	RELAPSING NEUROMYELITIS-OPTICA ; VISUAL-CORTEX ACTIVATION ; FRACTIONAL ANISOTROPY ; QUANTITATIVE-ANALYSIS ; TENSOR TRACTOGRAPHY ; BRAIN ; SCHIZOPHRENIA ; HUMANS ; TRACT ; FMRI
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000262397000019
引用统计	被引频次：77[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3098
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 2.Xuanwu Hosp Capital Med Univ, Dept Radiol, Beijing 100053, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Shu, Ni,Li, Jun,Li, Kuncheng,et al. Abnormal Diffusion of Cerebral White Matter in Early Blindness[J]. HUMAN BRAIN MAPPING,2009,30(1):220-227.
APA	Shu, Ni,Li, Jun,Li, Kuncheng,Yu, Chunshui,&Jiang, Tianzi.(2009).Abnormal Diffusion of Cerebral White Matter in Early Blindness.HUMAN BRAIN MAPPING,30(1),220-227.
MLA	Shu, Ni,et al."Abnormal Diffusion of Cerebral White Matter in Early Blindness".HUMAN BRAIN MAPPING 30.1(2009):220-227.