Knowledge Commons of Institute of Automation,CAS
Abnormal Diffusion of Cerebral White Matter in Early Blindness | |
Shu, Ni1; Li, Jun1; Li, Kuncheng2; Yu, Chunshui2; Jiang, Tianzi1 | |
发表期刊 | HUMAN BRAIN MAPPING |
2009 | |
卷号 | 30期号:1页码:220-227 |
文章类型 | Article |
摘要 | Early visual deprivation may lead to both abnormal and plastic changes in the visual and other systems of the brain. Such secondary changes in the gray matter of the early blind have been well studied, but not so well in the cerebral white matter whose subtle changes may be revealed by diffusion tensor imaging. The first purpose of this study is to explore the possible changed white matter regions of the early blind in whole brain manners, using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS) methods. The second purpose is to investigate the changes of diffusion eigenvalues in the abnormal white matter fiber tracts using tractography based group mapping analysis. From VBA of fractional anisotropy (FA) images, the significant changed white matter regions were the geniculocalcarine tract (GCT) and its adjacent regions. This finding was validated by TBSS method. Then we studied the changes of mean diffusivity (MD), FA, primary (lambda(1)) and transverse diffusivities (lambda(23)) in the GCT using tractography based group mapping analysis. We found the early blind had significantly lower FA (P < 0.0001), higher MD (P = 0.001) and lambda(23) (P < 0.0001) in the GCT. This pattern of diffusion changes is similar to findings seen in immaturity or axonal degeneration. Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind. Ham Brain Mapp 30:220-227, 2009. (c) 2007 Wiley-Liss, Inc. |
关键词 | Early Blind Diffusion Tensor Imaging Tractography Visual System |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | RELAPSING NEUROMYELITIS-OPTICA ; VISUAL-CORTEX ACTIVATION ; FRACTIONAL ANISOTROPY ; QUANTITATIVE-ANALYSIS ; TENSOR TRACTOGRAPHY ; BRAIN ; SCHIZOPHRENIA ; HUMANS ; TRACT ; FMRI |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000262397000019 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/3098 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 2.Xuanwu Hosp Capital Med Univ, Dept Radiol, Beijing 100053, Peoples R China |
第一作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Shu, Ni,Li, Jun,Li, Kuncheng,et al. Abnormal Diffusion of Cerebral White Matter in Early Blindness[J]. HUMAN BRAIN MAPPING,2009,30(1):220-227. |
APA | Shu, Ni,Li, Jun,Li, Kuncheng,Yu, Chunshui,&Jiang, Tianzi.(2009).Abnormal Diffusion of Cerebral White Matter in Early Blindness.HUMAN BRAIN MAPPING,30(1),220-227. |
MLA | Shu, Ni,et al."Abnormal Diffusion of Cerebral White Matter in Early Blindness".HUMAN BRAIN MAPPING 30.1(2009):220-227. |
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