Sex-Dependent Correlations between the Personality Dimension of Harm Avoidance and the Resting-State Functional Connectivity of Amygdala Subregions

	Sex-Dependent Correlations between the Personality Dimension of Harm Avoidance and the Resting-State Functional Connectivity of Amygdala Subregions
	Li, Ying 1; Qin, Wen 1; Jiang, Tianzi2 ; Zhang, Yunting 1; Yu, Chunshui 1
发表期刊	PLOS ONE
	2012-04-27
卷号	7 期号:4
文章类型	Article
摘要	Harm avoidance (HA) is a personality dimension involving the tendency to respond intensely to signals of aversive stimuli. Many previous neuroimaging studies have associated HA scores with the structural and functional organization of the amygdala, but none of these studies have evaluated the correlation between HA score and amygdala resting-state functional connectivity (rsFC). Moreover, the amygdala is not a homogeneous structure, and it has been divided into several structurally and functionally distinct subregions. Investigating the associations between HA score and properties of subregions of the amygdala could greatly improve our understanding of HA. In the present study, using a large sample of 291 healthy young adults, we aimed to uncover correlations between HA scores and the rsFCs of each amygdala subregion and to uncover possible sex-based differences in these correlations. We found that subregions of the amygdala showed different rsFC patterns, which contributed differently to individual HA scores. More specifically, HA scores were correlated with rsFCs between the laterobasal amygdala subregion and temporal and occipital cortices related to emotional information input, between the centromedial subregion and the frontal cortices associated with emotional output control, and between the superficial subregion and the frontal and temporal areas involved in both functions. Moreover, significant gender-based differences were uncovered in these correlations. Our findings provide a more detailed model of association between HA scores and amygdala rsFC, extend our understanding of the connectivity of subregions of the amygdala, and confirm sex-based differences in HA associations.
WOS标题词	Science & Technology
关键词[WOS]	GENERALIZED ANXIETY DISORDER ; POSITRON-EMISSION-TOMOGRAPHY ; CEREBRAL GLUCOSE-METABOLISM ; MAJOR DEPRESSION ; SOCIAL COGNITION ; CYTOARCHITECTONIC MAPS ; INDIVIDUAL-DIFFERENCES ; HIPPOCAMPAL VOLUME ; ANTERIOR CINGULATE ; GENDER-DIFFERENCES
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000305336000087
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3183
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Ying,Qin, Wen,Jiang, Tianzi,et al. Sex-Dependent Correlations between the Personality Dimension of Harm Avoidance and the Resting-State Functional Connectivity of Amygdala Subregions[J]. PLOS ONE,2012,7(4).
APA	Li, Ying,Qin, Wen,Jiang, Tianzi,Zhang, Yunting,&Yu, Chunshui.(2012).Sex-Dependent Correlations between the Personality Dimension of Harm Avoidance and the Resting-State Functional Connectivity of Amygdala Subregions.PLOS ONE,7(4).
MLA	Li, Ying,et al."Sex-Dependent Correlations between the Personality Dimension of Harm Avoidance and the Resting-State Functional Connectivity of Amygdala Subregions".PLOS ONE 7.4(2012).