CASIA OpenIR  > 中国科学院分子影像重点实验室
A Deep Learning Risk Prediction Model for Overall Survival in Patients with Gastric Cancer: A Multicenter Study
Zhang, Liwen1; Dong, Di1; Zhang, Wenjuan2; Hao, Xiaohan1; Fang, Mengjie1; Wang, Shuo1; Li, Wuchao3; Liu, Zaiyi4; Wang, Rongpin3; Zhou, Junlin2; Tian, Jie1
Source PublicationRadiotherapy and oncology
2020
Volume150Issue:1Pages:73-80
Abstract

Background and purpose: Risk prediction of overall survival (OS) is crucial for gastric cancer (GC) patients to assess the treatment programs and may guide personalized medicine. A novel deep learning (DL) model was proposed to predict the risk for OS based on computed tomography (CT) images. Materials and methods: We retrospectively collected 640 patients from three independent centers, which were divided into a training cohort (center 1 and center 2, n=518) and an external validation cohort (center 3, n=122). We developed a DL model based on the architecture of residual convolutional neural network. We augmented the size of training dataset by image transformations to avoid overfitting. We also developed radiomics and clinical models for comparison. The performance of the three models were comprehensively assessed. Results: Totally 518 patients were prepared by data augmentation and fed into DL model. The trained DL model significantly classified patients into high-risk and low-risk groups in training cohort (P-value<0.001, concordance index (C-index): 0.82, hazard ratio (HR): 9.79) and external validation cohort (P-value<0.001, C-index:0.78, HR: 11.76). Radiomics model was developed with selected 24 features and clinical model was developed with three significant clinical variables (P-value<0.05). The comparison illustrated DL model had the best performance for risk prediction of OS according to the C-index (training: DL vs Clinical vs Radiomics=0.82 vs 0.73 vs 0.66; external validation: 0.78 vs 0.71 vs 0.72). Conclusion: The DL model is a powerful model for risk assessment, and potentially serves as an individualized recommender for decision-making in GC patients.

KeywordGastric Cancer
DOI10.1016/j.radonc.2020.06.010
Indexed BySCI
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/40684
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiu, Zaiyi; Wang, Rongpin; Zhou, Junlin; Tian, Jie
Affiliation1.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
2.Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China
3.Department of Radiology, Guizhou Provincial People’s Hospital, Guiyang 550002, China
4.Department of Radiology, Guangdong General Hospital, Guangzhou 510080, China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Liwen,Dong, Di,Zhang, Wenjuan,et al. A Deep Learning Risk Prediction Model for Overall Survival in Patients with Gastric Cancer: A Multicenter Study[J]. Radiotherapy and oncology,2020,150(1):73-80.
APA Zhang, Liwen.,Dong, Di.,Zhang, Wenjuan.,Hao, Xiaohan.,Fang, Mengjie.,...&Tian, Jie.(2020).A Deep Learning Risk Prediction Model for Overall Survival in Patients with Gastric Cancer: A Multicenter Study.Radiotherapy and oncology,150(1),73-80.
MLA Zhang, Liwen,et al."A Deep Learning Risk Prediction Model for Overall Survival in Patients with Gastric Cancer: A Multicenter Study".Radiotherapy and oncology 150.1(2020):73-80.
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