Structural brain alterations in primary open angle glaucoma: a 3T MRI study

doi:10.1038/srep18969

	Structural brain alterations in primary open angle glaucoma: a 3T MRI study
	Wang, Jieqiong; Li, Ting; Sabel, Bernhard A.; Chen, Zhiqiang; Wen, Hongwei; Li, Jianhong; Xie, Xiaobin; Yang, Diya; Chen, Weiwei; Wang, Ningli; Xian, Junfang; He, Huiguang
发表期刊	SCIENTIFIC REPORTS
	2016-01-08
卷号	6 期号:页码:
文章类型	Article
摘要	Glaucoma is not only an eye disease but is also associated with degeneration of brain structures. We now investigated the pattern of visual and non-visual brain structural changes in 25 primary open angle glaucoma (POAG) patients and 25 age-gender-matched normal controls using T1-weighted imaging. MRI images were subjected to volume-based analysis (VBA) and surface-based analysis (SBA) in the whole brain as well as ROI-based analysis of the lateral geniculate nucleus (LGN), visual cortex (V1/2), amygdala and hippocampus. While VBA showed no significant differences in the gray matter volumes of patients, SBA revealed significantly reduced cortical thickness in the right frontal pole and ROI-based analysis volume shrinkage in LGN bilaterally, right V1 and left amygdala. Structural abnormalities were correlated with clinical parameters in a subset of the patients revealing that the left LGN volume was negatively correlated with bilateral cup-to-disk ratio (CDR), the right LGN volume was positively correlated with the mean deviation of the right visual hemifield, and the right V1 cortical thickness was negatively correlated with the right CDR in glaucoma. These results demonstrate that POAG affects both vision-related structures and non-visual cortical regions. Moreover, alterations of the brain visual structures reflect the clinical severity of glaucoma.
关键词	Primary Open Angle Glaucoma
WOS标题词	Science & Technology
DOI	10.1038/srep18969
关键词[WOS]	OPTICAL COHERENCE TOMOGRAPHY ; LATERAL GENICULATE-NUCLEUS ; VOXEL-BASED MORPHOMETRY ; HUMAN CEREBRAL-CORTEX ; DIFFUSION-TENSOR MR ; NERVE-FIBER LAYER ; VISUAL-CORTEX ; ALZHEIMERS-DISEASE ; AREAS V1 ; THICKNESS
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000368684100001
引用统计	被引频次：59[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/40831
专题	脑图谱与类脑智能实验室_神经计算与脑机交互
推荐引用方式 GB/T 7714	Wang, Jieqiong,Li, Ting,Sabel, Bernhard A.,et al. Structural brain alterations in primary open angle glaucoma: a 3T MRI study[J]. SCIENTIFIC REPORTS,2016,6():.
APA	Wang, Jieqiong.,Li, Ting.,Sabel, Bernhard A..,Chen, Zhiqiang.,Wen, Hongwei.,...&He, Huiguang.(2016).Structural brain alterations in primary open angle glaucoma: a 3T MRI study.SCIENTIFIC REPORTS,6(),.
MLA	Wang, Jieqiong,et al."Structural brain alterations in primary open angle glaucoma: a 3T MRI study".SCIENTIFIC REPORTS 6.(2016):.