Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI

doi:10.1111/liv.15231

	Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI
	Jiang, Hanyu 1; Wei, Jingwei2,3 ; Fu, Fangfang 4,5; Wei, Hong 1; Qin, Yun 1; Duan, Ting 1; Chen, Weixia 1; Xie, Kunlin 6; Lee, Jeong Min 7,8; Bashir, Mustafa R.9,10,11; Wang, Meiyun 4,5; Song, Bin 1; Tian, Jie 2,3,12,13,14
发表期刊	LIVER INTERNATIONAL
ISSN	1478-3223
	2022-03-11
页码	15
通讯作者	Wang, Meiyun(mywang@ha.edu.cn) ; Song, Bin(anicesong@vip.sina.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Background & Aims Microvascular invasion (MVI) is an important risk factor in hepatocellular carcinoma (HCC), but its diagnosis mandates postoperative histopathologic analysis. We aimed to develop and externally validate a predictive scoring system for MVI. Methods From July 2015 to November 2020, consecutive patients underwent surgery for HCC with preoperative gadoxetate disodium (EOB)-enhanced MRI was retrospectively enrolled. All MR images were reviewed independently by two radiologists who were blinded to the outcomes. In the training centre, a radio-clinical MVI score was developed via logistic regression analysis against pathology. In the testing centre, areas under the receiver operating curve (AUCs) of the MVI score and other previous MVI schemes were compared. Overall survival (OS) and recurrence-free survival (RFS) were analysed by the Kaplan-Meier method with the log-rank test. Results A total of 417 patients were included, 195 (47%) with pathologically-confirmed MVI. The MVI score included: non-smooth tumour margin (odds ratio [OR] = 4.4), marked diffusion restriction (OR = 3.0), internal artery (OR = 3.0), hepatobiliary phase peritumoral hypointensity (OR = 2.5), tumour multifocality (OR = 1.6), and serum alpha-fetoprotein >400 ng/mL (OR = 2.5). AUCs for the MVI score were 0.879 (training) and 0.800 (testing), significantly higher than those for other MVI schemes (testing AUCs: 0.648-0.684). Patients with model-predicted MVI had significantly shorter OS (median 61.0 months vs not reached, P < .001) and RFS (median 13.0 months vs. 42.0 months, P < .001) than those without. Conclusions A preoperative MVI score integrating five EOB-MRI features and serum alpha-fetoprotein level could accurately predict MVI and postoperative survival in HCC. Therefore, this score may aid in individualized treatment decision making.
关键词	diagnosis gadoxetate disodium-enhanced MRI hepatocellular carcinoma microvascular invasion survival
DOI	10.1111/liv.15231
关键词[WOS]	COMPUTED-TOMOGRAPHY ; RECURRENCE ; DIAGNOSIS ; RESECTION ; NOMOGRAM ; SYSTEM ; CANCER
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82101997] ; National Natural Science Foundation of China[62027 901] ; National Natural Science Foundation of China[81 227 901] ; National Natural Science Foundation of China[81 930 053] ; National Natural Science Foundation of China[82 001917] ; Science and Technology Support Program of Sichuan Province[2021YFS0141] ; Science and Technology Support Program of Sichuan Province[2021YFS0021] ; Ministry of Science and Technology of China[2017YFA0205200] ; Project of High-Level Talents Team Introduction in Zhuhai City[HLHPTP201703]
项目资助者	National Natural Science Foundation of China ; Science and Technology Support Program of Sichuan Province ; Ministry of Science and Technology of China ; Project of High-Level Talents Team Introduction in Zhuhai City
WOS研究方向	Gastroenterology & Hepatology
WOS类目	Gastroenterology & Hepatology
WOS记录号	WOS:000767145200001
出版者	WILEY
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47943
专题	中国科学院分子影像重点实验室
通讯作者	Wang, Meiyun; Song, Bin; Tian, Jie
作者单位	1.Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Beijing Key Lab Mol Imaging, Beijing, Peoples R China 4.Henan Prov Peoples Hosp, Dept Med Imaging, Zhengzhou 450003, Henan, Peoples R China 5.Zhengzhou Univ, Dept Med Imaging, Peoples Hosp, Zhengzhou, Peoples R China 6.Sichuan Univ, West China Hosp, Dept Liver Surg & Liver Transplantat, Chengdu, Peoples R China 7.Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea 8.Seoul Natl Univ, Coll Med, Seoul, South Korea 9.Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA 10.Duke Univ, Med Ctr, Ctr Adv Magnet Resonance Med, Durham, NC USA 11.Duke Univ, Med Ctr, Div Gastroenterol, Durham, NC 27710 USA 12.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China 13.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China 14.Beihang Univ, Minist Ind & Informat Technol, Key Lab Big Data Based Precis Med, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Jiang, Hanyu,Wei, Jingwei,Fu, Fangfang,et al. Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI[J]. LIVER INTERNATIONAL,2022:15.
APA	Jiang, Hanyu.,Wei, Jingwei.,Fu, Fangfang.,Wei, Hong.,Qin, Yun.,...&Tian, Jie.(2022).Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI.LIVER INTERNATIONAL,15.
MLA	Jiang, Hanyu,et al."Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI".LIVER INTERNATIONAL (2022):15.