Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial

doi:10.1097/XCS.0000000000000029

	Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial
	He, Kunshan 2,3,4,5; Hong, Xiaopeng 1; Chi, Chongwei6 ; Cai, Chaonong 1; An, Yu 2,3; Li, Peiping 1; Liu, Xialei 1; Shan, Hong 1; Tian, Jie 2,3,6; Li, Jian 1
发表期刊	JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
ISSN	1072-7515
	2022-02-01
卷号	234 期号:2 页码:130-137
通讯作者	Li, Jian(lijian5@mail.sysu.edu.cn)
摘要	BACKGROUND: The application of indocyanine green fluorescence-guided hepatectomy for liver metastases from colorectal cancer is in the preliminary stage of clinical practice; thus, its efficacy needs to be determined. This study compared the number of intrahepatic colorectal liver metastases detected intraoperatively and postoperative recovery data between patients who underwent traditional hepatectomy (nonindocyanine green group) and traditional hepatectomy plus intraoperative indocyanine green fluorescence imaging (indocyanine green group). STUDY DESIGN: Between January 2018 and March 2020, patients with potentially resectable colorectal liver metastases were randomly assigned to the nonindocyanine green or indocyanine green group. The number of intrahepatic colorectal liver metastases identified intraoperatively and based on postoperative recovery data were compared between both groups. RESULTS: Overall, we recruited 80 patients, among whom 72 eligible patients were randomly assigned. After allocation, 64 patients, comprising 32 in each group, underwent the allocated intervention and follow-up. Compared with the nonindocyanine green group, the mean number of intrahepatic colorectal liver metastases identified intraoperatively in the indocyanine green group was significantly greater (mean [standard deviation], 3.03 [1.58] vs 2.28 [1.35]; p = 0.045), the postoperative hospital stay was shorter (p = 0.012) and the 1-year recurrence rate was also lower (p = 0.017). Postoperative complications and 90-day mortality were comparable, with no statistical differences. CONCLUSIONS: Indocyanine green fluorescence imaging significantly increases the number of intrahepatic colorectal liver metastases identified and reduces postoperative hospital stay and 1-year recurrence rate without increasing hepatectomy-related complications and mortality rates. (C) 2022 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.
DOI	10.1097/XCS.0000000000000029
关键词[WOS]	INTRAOPERATIVE ULTRASOUND ; INDOCYANINE GREEN ; RESECTION ; CANCER
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81971773] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[82001984] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science & Technology Commission[Z201100006820017] ; Beijing Municipal Science & Technology Commission[Z19111000110000] ; Project of High-Level Talents Team Introduction in Zhuhai City[HLHPTP201703]
项目资助者	Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Project of High-Level Talents Team Introduction in Zhuhai City
WOS研究方向	Surgery
WOS类目	Surgery
WOS记录号	WOS:000765911100006
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/48000
专题	中国科学院分子影像重点实验室
通讯作者	Li, Jian
作者单位	1.Sun Yat Sen Univ, Affiliated Hosp 5, Zhuhai 519099, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing, Peoples R China 3.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Software, State Key Lab Comp Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Software, Beijing Key Lab Human Comp Interact, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
推荐引用方式 GB/T 7714	He, Kunshan,Hong, Xiaopeng,Chi, Chongwei,et al. Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial[J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS,2022,234(2):130-137.
APA	He, Kunshan.,Hong, Xiaopeng.,Chi, Chongwei.,Cai, Chaonong.,An, Yu.,...&Li, Jian.(2022).Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial.JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS,234(2),130-137.
MLA	He, Kunshan,et al."Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial".JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 234.2(2022):130-137.