CASIA OpenIR  > 脑网络组研究
Uncovering the genetic profiles underlying the intrinsic organization of the human cerebellum
Wang, Yaping1,2,3,4; Chai, Lin2,3,4; Chu, Congying2,3,4; Li, Deying2,3,4; Gao, Chaohong1,2,3,4; Wu, Xia2,3,4; Yang, Zhengyi2,3,4; Zhang, Yu5; Xu, Junhai6; Nyengaard, Jens Randel1,7,8; Eickhoff, Simon B.9,10; Liu, Bing11; Madsen, Kristoffer Hougaard1,12,13; Jiang, Tianzi1,2,3,4,14; Fan, Lingzhong1,2,3,4,14
Source PublicationMOLECULAR PSYCHIATRY
ISSN1359-4184
2022-03-09
Pages16
Corresponding AuthorChu, Congying(chucongying@gmail.com) ; Fan, Lingzhong(lingzhong.fan@ia.ac.cn)
AbstractThe functional diversity of the human cerebellum is largely believed to be derived more from its extensive connections rather than being limited to its mostly invariant architecture. However, whether and how the determination of cerebellar connections in its intrinsic organization interact with microscale gene expression is still unknown. Here we decode the genetic profiles of the cerebellar functional organization by investigating the genetic substrates simultaneously linking cerebellar functional heterogeneity and its drivers, i.e., the connections. We not only identified 443 network-specific genes but also discovered that their co-expression pattern correlated strongly with intra-cerebellar functional connectivity (FC). Ninety of these genes were also linked to the FC of cortico-cerebellar cognitive-limbic networks. To further discover the biological functions of these genes, we performed a "virtual gene knock-out" by observing the change in the coupling between gene co-expression and FC and divided the genes into two subsets, i.e., a positive gene contribution indicator (GCI(+)) involved in cerebellar neurodevelopment and a negative gene set (GCI(-)) related to neurotransmission. A more interesting finding is that GCI(-) is significantly linked with the cerebellar connectivity-behavior association and many recognized brain diseases that are closely linked with the cerebellar functional abnormalities. Our results could collectively help to rethink the genetic substrates underlying the cerebellar functional organization and offer possible micro-macro interacted mechanistic interpretations of the cerebellum-involved high order functions and dysfunctions in neuropsychiatric disorders.
DOI10.1038/s41380-022-01489-8
WOS KeywordFUNCTIONAL CONNECTIVITY ; EXPRESSION ; THOUGHT ; DYSMETRIA ; COGNITION ; NETWORK ; NEUROTRANSMITTERS ; MICROSCALE ; DISORDERS ; DIVERSITY
Indexed BySCI
Language英语
Funding ProjectScience and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project[2021ZD0200203] ; Natural Science Foundation of China[82072099] ; Natural Science Foundation of China[91432302] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030214] ; Youth Innovation Promotion Association ; Major Scientific Project of Zhejiang Lab[2021ND0PI01] ; NIH Blueprint for Neuroscience Research[1U54MH091657] ; McDonnell Center for Systems Neuroscience at Washington University ; Beijing Advanced Discipline Fund
Funding OrganizationScience and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project ; Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Youth Innovation Promotion Association ; Major Scientific Project of Zhejiang Lab ; NIH Blueprint for Neuroscience Research ; McDonnell Center for Systems Neuroscience at Washington University ; Beijing Advanced Discipline Fund
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS IDWOS:000766422100003
PublisherSPRINGERNATURE
Sub direction classification脑网络分析
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/48003
Collection脑网络组研究
Corresponding AuthorChu, Congying; Fan, Lingzhong
Affiliation1.Univ Chinese Acad Sci, Sino Danish Ctr, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Zhejiang Lab, Res Ctr Healthcare Data Sci, Hangzhou 311100, Peoples R China
6.Tianjin Univ, Sch Comp Sci & Technol, Tianjin Key Lab Cognit Comp & Applicat, Tianjin 300350, Peoples R China
7.Aarhus Univ, Core Ctr Mol Morphol, Dept Clin Med, Sect Stereol & Microscopy, DK-8000 Aarhus, Denmark
8.Aarhus Univ Hosp, Dept Pathol, DK-8200 Aarhus, Denmark
9.Res Ctr Julich, Inst Neurosci & Med INM 7 Brain & Behav, D-52425 Julich, Germany
10.Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, D-40225 Dusseldorf, Germany
11.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
12.Tech Univ Denmark, Dept Informat & Math Modelling, DK-2800 Lyngby, Denmark
13.Copenhagen Univ Hosp Amager & Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, DK-2650 Hvidovre, Denmark
14.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yaping,Chai, Lin,Chu, Congying,et al. Uncovering the genetic profiles underlying the intrinsic organization of the human cerebellum[J]. MOLECULAR PSYCHIATRY,2022:16.
APA Wang, Yaping.,Chai, Lin.,Chu, Congying.,Li, Deying.,Gao, Chaohong.,...&Fan, Lingzhong.(2022).Uncovering the genetic profiles underlying the intrinsic organization of the human cerebellum.MOLECULAR PSYCHIATRY,16.
MLA Wang, Yaping,et al."Uncovering the genetic profiles underlying the intrinsic organization of the human cerebellum".MOLECULAR PSYCHIATRY (2022):16.
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