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Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study
Yang, Yongfeng1,2,3; Li, Xue1,2,3; Cui, Yue4,5,6; Liu, Kang1,2,3; Qu, Haoyang7; Lu, Yanli1; Li, Wenqiang1,2,3; Zhang, Luwen1,2,3; Zhang, Yan1,2,3; Song, Jinggui1,2,3; Lv, Luxian1,2,3
Source PublicationFRONTIERS IN NEUROSCIENCE
2022-06-10
Volume16Pages:8
Corresponding AuthorSong, Jinggui(songjg62@126.com) ; Lv, Luxian(lvx928@126.com)
AbstractSchizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are severe psychiatric disorders and share common characteristics not only in clinical symptoms but also in neuroimaging. The purpose of this study was to examine common and specific neuroanatomical features in individuals with these three psychiatric conditions. In this study, 70 patients with SZ, 85 patients with MDD, 42 patients with BD, and 95 healthy controls (HCs) were recruited. Voxel-based morphometry (VBM) analysis was used to explore brain imaging characteristics. Psychopathology was assessed using the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Young Mania Rating Scale (YMRS), and the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed using the digit symbol substitution test (DSST), forward-digital span (DS), backward-DS, and semantic fluency. Common reduced gray matter volume (GMV) in the orbitofrontal cortex (OFC) region was found across the SZ, MDD, and BD. Specific reduced GMV of brain regions was also found. For patients with SZ, we found reduced GMV in the frontal lobe, temporal pole, occipital lobe, thalamus, hippocampus, and cerebellum. For patients with MDD, we found reduced GMV in the frontal and temporal lobes, insular cortex, and occipital regions. Patients with BD had reduced GMV in the medial OFC, inferior temporal and fusiform regions, insular cortex, hippocampus, and cerebellum. Furthermore, the OFC GMV was correlated with processing speed as assessed with the DSST across four groups (r = 0.17, p = 0.004) and correlated with the PANSS positive symptoms sub-score in patients with SZ (r = - 0.27, p = 0.026). In conclusion, common OFC alterations in SZ, MDD, and BD provided evidence that this region dysregulation may play a critical role in the pathophysiology of these three psychiatric disorders.
Keywordschizophrenia major depressive disorder bipolar disorder gray matter volume (GMV) psychopathology
DOI10.3389/fnins.2022.919272
WOS KeywordVOXEL-BASED MORPHOMETRY ; AMYGDALA VOLUMES ; YOUNG-ADULTS ; ABNORMALITIES ; CONNECTIVITY ; ASSOCIATION ; INVENTORY ; PATTERNS ; CHILDREN ; COMMON
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000815676000001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/49208
Collection脑网络组研究
Corresponding AuthorSong, Jinggui; Lv, Luxian
Affiliation1.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China
2.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
3.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Xinxiang Med Univ, Clin Coll 2, Dept Psychiat, Xinxiang, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yongfeng,Li, Xue,Cui, Yue,et al. Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study[J]. FRONTIERS IN NEUROSCIENCE,2022,16:8.
APA Yang, Yongfeng.,Li, Xue.,Cui, Yue.,Liu, Kang.,Qu, Haoyang.,...&Lv, Luxian.(2022).Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study.FRONTIERS IN NEUROSCIENCE,16,8.
MLA Yang, Yongfeng,et al."Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study".FRONTIERS IN NEUROSCIENCE 16(2022):8.
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