CASIA OpenIR  > 中国科学院分子影像重点实验室
DH-Mammo PET: a dual-head positron emission mammography system for breast imaging
Shi, Yu1,2,3,4; Wang, Yirong5; Zhou, Jianwei1,2,3,4; Zhu, Yuzhen6; Lyu, Xudong6; Hui, Hui7,8; Wen, Bo1,2,3,4; Liu, Yanyun1,2,3,4; Li, Lei1,2,3,4; Li, Juntao1,2,3,4; Meng, Fanzhen1,2,9; Kang, Fei5; Zhu, Shouping1,2,3,4
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
ISSN0031-9155
2022-10-21
Volume67Issue:20Pages:21
Corresponding AuthorMeng, Fanzhen(mengfz0316@xidian.edu.cn) ; Kang, Fei(fmmukf@qq.com) ; Zhu, Shouping(spzhu@xidian.edu.cn)
AbstractObjective. To develop a simultaneous positron emission tomography-Optical (OPET) breast imaging dual-head PET subsystem, called DH-Mammo PET, for accurate, early diagnosis and efficacy assessment of breast cancer with high resolution and sensitivity. Approach. We developed a breast-dedicated PET based on LYSO crystal, silicon photomultiplier array and multi-voltage threshold sampling technique. It consists of two detector heads, each with a detection area of 216 mm x 145.5 mm. The distance between the detector heads is fixed at 120 mm. In order to extract coincidences and correct data, GPU-based software coincidence processing, random, scatter, normalization, gap-filling and attenuation corrections were applied in turn. The images were reconstructed using maximum likelihood expectation maximization with depth of interaction (DOI) modeling. The performance of DH-Mammo PET was evaluated referring to NEMA NU 4-2008, NU 2-2007 and Chinese industry recommended standard YY/T 1835-2022. Besides, several clinical patient images of DH-Mammo PET were compared with those of a whole-body PET/CT. Main results. The energy resolution was 14.5%, and time resolution was < 1.31 ns. Indicated by the Na-22 point source imaging, its spatial resolution was 2.60 mm (5.40 mm), 1.00 mm (1.04 mm), and 0.96 mm (0.93 mm) in the X, Y and Z directions, respectively, using the system response matrix with (without) DOI modeling. Indicated by the Derenzo phantom imaging, the spatial resolution was similar to 3.0 mm, <1.2 mm, and X, Y and Z directions. The system sensitivity was 6.87%, 4.89% and 3.37% with an energy window of 100-800, 250-750 and 350-650 keV, respectively. The scatter fraction was 26.43%, and the peak NECR was 162.6 kcps at 24.1 MBq for the modified rat-like phantom. As for the recovery coefficients, they ranged from 0.15 to 1.04 for rods between 1 and 5 mm obtained with a NEMA image quality phantom. The spill-over ratio for the air-filled and water-filled chamber was 0.05 and 0.11, respectively. DH-Mammo PET can provide more image details in clinical experiments and fulfil a fast scan with 60-120 s acquisition time. Significance. Good spatial resolution and high sensitivity of DH-Mammo PET would enable fast and accurate PET imaging of the breast. Besides, combining the DH-Mammo PET with the diffuse optical tomography would make full use of tumor metabolic imaging and tissue endogenous optical imaging, which would improve the accuracy of early clinical diagnosis of small lesions of breast cancers.
Keywordperformance evaluation mammography dual-head PET system PET-optical
DOI10.1088/1361-6560/ac934c
WOS KeywordWHOLE-BODY PET ; PERFORMANCE EVALUATION ; SCANNER ; RECONSTRUCTION ; CANCER ; ACCURACY ; NORMALIZATION ; RESOLUTION ; DESIGN
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFC0103800] ; National Natural Science Foundation of China[61901339] ; National Natural Science Foundation of China[62071362] ; Natural Science Foundation of Shaanxi Province[2021SF-169] ; Natural Science Foundation of Shaanxi Province[2021SF-131] ; Natural Science Foundation of Hebei Province[H2022206124] ; Fundamental Research Funds for the Central Universities[JB211209] ; CAS Youth Innovation Promotion Association[2018167] ; CAS Key Technology Talent Program
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shaanxi Province ; Natural Science Foundation of Hebei Province ; Fundamental Research Funds for the Central Universities ; CAS Youth Innovation Promotion Association ; CAS Key Technology Talent Program
WOS Research AreaEngineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectEngineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000864901500001
PublisherIOP Publishing Ltd
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/50338
Collection中国科学院分子影像重点实验室
Corresponding AuthorMeng, Fanzhen; Kang, Fei; Zhu, Shouping
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
3.Xidian Univ, Sch Life Sci & Technol, Int Joint Res Ctr Adv Med Imaging & Intelligent D, Xian 710126, Shaanxi, Peoples R China
4.Xidian Univ, Sch Life Sci & Technol, Xian Key Lab Intelligent Sensing & Regulat Trans, Xian 710126, Shaanxi, Peoples R China
5.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
6.Raycan Technol Co Ltd Suzhou, Suzhou 215163, Jiangsu, Peoples R China
7.Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
8.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
9.Hebei Med Univ, Sch Med Imaging, Shijiazhuang 050017, Hebei, Peoples R China
Recommended Citation
GB/T 7714
Shi, Yu,Wang, Yirong,Zhou, Jianwei,et al. DH-Mammo PET: a dual-head positron emission mammography system for breast imaging[J]. PHYSICS IN MEDICINE AND BIOLOGY,2022,67(20):21.
APA Shi, Yu.,Wang, Yirong.,Zhou, Jianwei.,Zhu, Yuzhen.,Lyu, Xudong.,...&Zhu, Shouping.(2022).DH-Mammo PET: a dual-head positron emission mammography system for breast imaging.PHYSICS IN MEDICINE AND BIOLOGY,67(20),21.
MLA Shi, Yu,et al."DH-Mammo PET: a dual-head positron emission mammography system for breast imaging".PHYSICS IN MEDICINE AND BIOLOGY 67.20(2022):21.
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