Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications | |
Cheng, Zhongquan1,2; Ma, Jiaojiao3; Yin, Lin2,4 ; Yu, Leyi1; Yuan, Zhu1; Zhang, Bo3; Tian, Jie2,5; Du, Yang2,4
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| Source Publication | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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| ISSN | 1619-7070 |
| 2022-11-29 | |
| Pages | 23 |
| Corresponding Author | Yuan, Zhu(BJFH_yz_paper@163.com) ; Zhang, Bo(thyroidus@163.com) ; Tian, Jie(tian@ieee.org) ; Du, Yang(yang.du@ia.ac.cn) |
| Abstract | Lymph node metastasis is an indicator of the invasiveness and aggressiveness of cancer. It is a vital prognostic factor in clinical staging of the disease and therapeutic decision-making. Patients with positive metastatic lymph nodes are likely to develop recurrent disease, distant metastasis, and succumb to death in the coming few years. Lymph node dissection and histological analysis are needed to detect whether regional lymph nodes have been infiltrated by cancer cells and determine the likely outcome of treatment and the patient's chances of survival. However, these procedures are invasive, and tissue biopsies are prone to sampling error. In recent years, advanced molecular imaging with novel imaging probes has provided new technologies that are contributing to comprehensive management of cancer, including non-invasive investigation of lymphatic drainage from tumors, identifying metastatic lymph nodes, and guiding surgeons to operate efficiently in patients with complex lesions. In this review, first, we outline the current status of different molecular imaging modalities applied for lymph node metastasis management. Second, we summarize the multi-functional imaging probes applied with the different imaging modalities as well as applications of cancer lymph node metastasis from preclinical studies to clinical translations. Third, we describe the limitations that must be considered in the field of molecular imaging for improved detection of lymph node metastasis. Finally, we propose future directions for molecular imaging technology that will allow more personalized treatment plans for patients with lymph node metastasis. |
| Keyword | Molecular imaging Lymph node metastasis Cancer Imaging probes Imaging biomarkers |
| DOI | 10.1007/s00259-022-06056-5 |
| WOS Keyword | EPITHELIAL-MESENCHYMAL TRANSITION ; SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; INDOCYANINE GREEN ; EXTRACELLULAR VESICLES ; ADVERSE-REACTIONS ; TIM-3 EXPRESSION ; GUIDED SURGERY ; OVARIAN-CANCER ; FLUORESCENCE |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Beijing Natural Science Foundation[7212207] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] |
| Funding Organization | Beijing Natural Science Foundation ; National Natural Science Foundation of China |
| WOS Research Area | Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000889438400001 |
| Publisher | SPRINGER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/50834 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Yuan, Zhu; Zhang, Bo; Tian, Jie; Du, Yang |
| Affiliation | 1.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.China Japan Friendship Hosp, Dept Med Ultrason, Yinghua East Rd 2, Beijing 100029, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med Sci & Engn, Beijing 100191, Peoples R China |
| First Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Corresponding Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Cheng, Zhongquan,Ma, Jiaojiao,Yin, Lin,et al. Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:23. |
| APA | Cheng, Zhongquan.,Ma, Jiaojiao.,Yin, Lin.,Yu, Leyi.,Yuan, Zhu.,...&Du, Yang.(2022).Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,23. |
| MLA | Cheng, Zhongquan,et al."Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):23. |
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