Knowledge Commons of Institute of Automation,CAS
Driving brain state transitions in major depressive disorder through external stimulation | |
Shengpei Wang; Hongwei Wen; Shuang Qiu; Peng Xie; Jiang Qiu; Huiguang He | |
发表期刊 | Human Brain Mapping |
2022-12 | |
卷号 | 43期号:17页码:5326-5339 |
摘要 | Major depressive disorder (MDD) as a dysfunction of neural circuits and brain networks has been established in modern neuroimaging sciences. However,the brain state transitions between MDD and health through external stimulation remain unclear,which limits translation to clinical contexts and demonstrable clinical utility. We propose a framework of the large-scale whole-brain network model for MDD linking the underlying anatomical connectivity with functional dynamics obtained from diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). Then,we further explored the optimal brain regions to promote the transition of brain states between MDD and health through external stimulation of the model. Based on the whole-brain model successfully fitting the brain state space in MDD and the health,we demonstrated that the transition from MDD to health is achieved by the excitatory activation of the limbic system and from health to MDD by the inhibitory stimulation of the reward circuit. Our finding provides novel biophysical evidence for the neural mechanism of MDD and its recovery and allows the discovery of new stimulation targets for MDD recovery. |
DOI | 10.1002/hbm.26006 |
收录类别 | SCI |
语种 | 英语 |
七大方向——子方向分类 | 脑机接口 |
国重实验室规划方向分类 | 人工智能基础前沿理论 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/50879 |
专题 | 脑图谱与类脑智能实验室_神经计算与脑机交互 |
通讯作者 | Jiang Qiu; Huiguang He |
推荐引用方式 GB/T 7714 | Shengpei Wang,Hongwei Wen,Shuang Qiu,et al. Driving brain state transitions in major depressive disorder through external stimulation[J]. Human Brain Mapping,2022,43(17):5326-5339. |
APA | Shengpei Wang,Hongwei Wen,Shuang Qiu,Peng Xie,Jiang Qiu,&Huiguang He.(2022).Driving brain state transitions in major depressive disorder through external stimulation.Human Brain Mapping,43(17),5326-5339. |
MLA | Shengpei Wang,et al."Driving brain state transitions in major depressive disorder through external stimulation".Human Brain Mapping 43.17(2022):5326-5339. |
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