CASIA OpenIR  > 类脑智能研究中心  > 神经计算与脑机交互
Driving brain state transitions in major depressive disorder through external stimulation
Shengpei Wang; Hongwei Wen; Shuang Qiu; Peng Xie; Jiang Qiu; Huiguang He
发表期刊Human Brain Mapping
2022-12
卷号43期号:17页码:5326-5339
摘要

Major depressive disorder (MDD) as a dysfunction of neural circuits and brain networks has been established in modern neuroimaging sciences. However,the brain state transitions between MDD and health through external stimulation remain unclear,which limits translation to clinical contexts and demonstrable clinical utility. We propose a framework of the large-scale whole-brain network model for MDD linking the underlying anatomical connectivity with functional dynamics obtained from diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). Then,we further explored the optimal brain regions to promote the transition of brain states between MDD and health through external stimulation of the model. Based on the whole-brain model successfully fitting the brain state space in MDD and the health,we demonstrated that the transition from MDD to health is achieved by the excitatory activation of the limbic system and from health to MDD by the inhibitory stimulation of the reward circuit. Our finding provides novel biophysical evidence for the neural mechanism of MDD and its recovery and allows the discovery of new stimulation targets for MDD recovery.

DOI10.1002/hbm.26006
收录类别SCI
语种英语
七大方向——子方向分类脑机接口
国重实验室规划方向分类人工智能基础前沿理论
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/50879
专题类脑智能研究中心_神经计算与脑机交互
通讯作者Jiang Qiu; Huiguang He
推荐引用方式
GB/T 7714
Shengpei Wang,Hongwei Wen,Shuang Qiu,et al. Driving brain state transitions in major depressive disorder through external stimulation[J]. Human Brain Mapping,2022,43(17):5326-5339.
APA Shengpei Wang,Hongwei Wen,Shuang Qiu,Peng Xie,Jiang Qiu,&Huiguang He.(2022).Driving brain state transitions in major depressive disorder through external stimulation.Human Brain Mapping,43(17),5326-5339.
MLA Shengpei Wang,et al."Driving brain state transitions in major depressive disorder through external stimulation".Human Brain Mapping 43.17(2022):5326-5339.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
J77-Human Brain Mapp(3245KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shengpei Wang]的文章
[Hongwei Wen]的文章
[Shuang Qiu]的文章
百度学术
百度学术中相似的文章
[Shengpei Wang]的文章
[Hongwei Wen]的文章
[Shuang Qiu]的文章
必应学术
必应学术中相似的文章
[Shengpei Wang]的文章
[Hongwei Wen]的文章
[Shuang Qiu]的文章
相关权益政策
暂无数据
收藏/分享
文件名: J77-Human Brain Mapping - 2022 - Wang - Driving brain state transitions in major depressive disorder through external.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。