CASIA OpenIR  > 脑图谱与类脑智能实验室  > 神经计算与脑机交互
Driving brain state transitions in major depressive disorder through external stimulation
Shengpei Wang; Hongwei Wen; Shuang Qiu; Peng Xie; Jiang Qiu; Huiguang He
Source PublicationHuman Brain Mapping
2022-12
Volume43Issue:17Pages:5326-5339
Abstract

Major depressive disorder (MDD) as a dysfunction of neural circuits and brain networks has been established in modern neuroimaging sciences. However,the brain state transitions between MDD and health through external stimulation remain unclear,which limits translation to clinical contexts and demonstrable clinical utility. We propose a framework of the large-scale whole-brain network model for MDD linking the underlying anatomical connectivity with functional dynamics obtained from diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). Then,we further explored the optimal brain regions to promote the transition of brain states between MDD and health through external stimulation of the model. Based on the whole-brain model successfully fitting the brain state space in MDD and the health,we demonstrated that the transition from MDD to health is achieved by the excitatory activation of the limbic system and from health to MDD by the inhibitory stimulation of the reward circuit. Our finding provides novel biophysical evidence for the neural mechanism of MDD and its recovery and allows the discovery of new stimulation targets for MDD recovery.

DOI10.1002/hbm.26006
Indexed BySCI
Language英语
Sub direction classification脑机接口
planning direction of the national heavy laboratory人工智能基础前沿理论
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/50879
Collection脑图谱与类脑智能实验室_神经计算与脑机交互
Corresponding AuthorJiang Qiu; Huiguang He
Recommended Citation
GB/T 7714
Shengpei Wang,Hongwei Wen,Shuang Qiu,et al. Driving brain state transitions in major depressive disorder through external stimulation[J]. Human Brain Mapping,2022,43(17):5326-5339.
APA Shengpei Wang,Hongwei Wen,Shuang Qiu,Peng Xie,Jiang Qiu,&Huiguang He.(2022).Driving brain state transitions in major depressive disorder through external stimulation.Human Brain Mapping,43(17),5326-5339.
MLA Shengpei Wang,et al."Driving brain state transitions in major depressive disorder through external stimulation".Human Brain Mapping 43.17(2022):5326-5339.
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