Evaluation of residual cognition in patients with disorders of consciousness based on functional near-infrared spectroscopy

doi:10.1117/1.NPh.10.2.025003

	Evaluation of residual cognition in patients with disorders of consciousness based on functional near-infrared spectroscopy
	Si, Juanning1 ; Yang, Yi 2; Xu, Long 2; Xu, Tianshuai 1; Liu, Hao3,4 ; Zhang, Yujin3,4 ; Jing, Rixing1 ; Li, Jinglian 5; Wang, Dongdong5 ; Wu, Sijin 1; He, Jianghong 2
发表期刊	NEUROPHOTONICS
ISSN	2329-423X
	2023-04-01
卷号	10 期号:2 页码:20
通讯作者	Si, Juanning(sijuanning@bistu.edu.cn) ; He, Jianghong(he_jianghong@sina.cn)
摘要	Significance: Accurate evaluation of consciousness in patients with prolonged disorders of consciousness (DOC) is critical for designing therapeutic plans, determining rehabilitative services, and predicting prognosis. Effective ways for detecting consciousness in patients with DOC are still needed.Aim: Evaluation of the residual awareness in patients with DOC and investigation of the spatiotemporal differences in the hemodynamic responses between the minimally conscious state (MCS) and the unresponsive wakefulness syndrome (UWS) groups using active command-driven motor imagery (MI) tasks.Approach: In this study, functional near-infrared spectroscopy (fNIRS) was used to measure the changes of hemodynamic responses in 19 patients with DOC (9 MCS and 10 UWS) using active command-driven MI tasks. The characteristics of the hemodynamic responses were extracted to compare the differences between the MCS and UWS groups. Moreover, the correlations between the hemodynamic responses and the clinical behavioral evaluations were also studied.Results: The results showed significant differences in the spatiotemporal distribution of the hemodynamic responses between the MCS and UWS groups. For the patients with MCS, significant increases in task-evoked hemodynamic responses occurred during the "YES" questions of the command-driven MI tasks. Importantly, these changes were significantly correlated with their coma-recovery scale-revised (CRS-R) scores. However, for the patients with UWS, no significant changes of the hemodynamic responses were found. Additionally, the results did not show any statistical correlation between the hemodynamic responses and their CRS-R scores.Conclusions: The fNIRS-based command-driven MI tasks can be used as a promising tool for detecting residual awareness in patients with DOC. We hope that the findings and the active paradigm used in this study will provide useful insights into the diagnosis, therapy, and prognosis of this challenging patient population.
关键词	disorders of consciousness functional near-infrared spectroscopy residual awareness motor imagery hemodynamic response
DOI	10.1117/1.NPh.10.2.025003
关键词[WOS]	MOTOR IMAGERY ; BRAIN ACTIVITY ; RECOVERY ; FNIRS ; OXYGENATION ; STATE
收录类别	SCI
语种	英语
资助项目	Beijing Natural Science Foundation[4214080] ; Beijing Natural Science Foundation[7232049] ; Beijing Natural Science Foundation[7214299] ; Key Collaborative Research Program of the Alliance of International Science Organizations[ANSO-CR-KP-2022-10] ; Ramp;D Program of Beijing Municipal Education Commission[KM202011232008] ; National Natural Science Foundation of China[81871398] ; National Natural Science Foundation of China[81600919]
项目资助者	Beijing Natural Science Foundation ; Key Collaborative Research Program of the Alliance of International Science Organizations ; Ramp;D Program of Beijing Municipal Education Commission ; National Natural Science Foundation of China
WOS研究方向	Neurosciences & Neurology ; Optics
WOS类目	Neurosciences ; Optics
WOS记录号	WOS:001031067800017
出版者	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53913
专题	脑图谱与类脑智能实验室_类脑认知计算
通讯作者	Si, Juanning; He, Jianghong
作者单位	1.Beijing Informat Sci & Technol Univ, Sch Instrumentat Sci & Optoelect Engn, Beijing, Peoples R China 2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 5.Sanhe Yanjiao Fuhe First Hosp, Dept Neurosurg, Langfang, Peoples R China
推荐引用方式 GB/T 7714	Si, Juanning,Yang, Yi,Xu, Long,et al. Evaluation of residual cognition in patients with disorders of consciousness based on functional near-infrared spectroscopy[J]. NEUROPHOTONICS,2023,10(2):20.
APA	Si, Juanning.,Yang, Yi.,Xu, Long.,Xu, Tianshuai.,Liu, Hao.,...&He, Jianghong.(2023).Evaluation of residual cognition in patients with disorders of consciousness based on functional near-infrared spectroscopy.NEUROPHOTONICS,10(2),20.
MLA	Si, Juanning,et al."Evaluation of residual cognition in patients with disorders of consciousness based on functional near-infrared spectroscopy".NEUROPHOTONICS 10.2(2023):20.