Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep

doi:10.1038/s42003-023-05439-0

	Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep
	Cao, Yutao 1,2,3; Ai, Yue 1,2,3; Zhang, Xiaosheng 4; Zhang, Jinlong 4; Long, Xianlei5 ; Zhu, Yaning 1,2,3; Wang, Linli 1,2,3; Gu, Qingyi5 ; Han, Hongbing 1,2,3,6
发表期刊	COMMUNICATIONS BIOLOGY
	2023-10-23
卷号	6 期号:1 页码:20
通讯作者	Han, Hongbing(hanhongbing@cau.edu.cn)
摘要	Hypertrophy and fiber transformation are two prominent features of postnatal skeletal muscle development. However, the role of epigenetic modifications is less understood. ATAC-seq, whole genome bisulfite sequencing, and RNA-seq were applied to investigate the epigenetic dynamics of muscle in Hu sheep at 3 days, 3 months, 6 months, and 12 months after birth. All 6865 differentially expressed genes were assigned into three distinct tendencies, highlighting the balanced protein synthesis, accumulated immune activities, and restrained cell division in postnatal development. We identified 3742 differentially accessible regions and 11799 differentially methylated regions that were associated with muscle-development-related pathways in certain stages, like D3-M6. Transcription factor network analysis, based on genomic loci with high chromatin accessibility and low methylation, showed that ARID5B, MYOG, and ENO1 were associated with muscle hypertrophy, while NR1D1, FADS1, ZFP36L2, and SLC25A1 were associated with muscle fiber transformation. Taken together, these results suggest that DNA methylation and chromatin accessibility contributed toward regulating the growth and fiber transformation of postnatal skeletal muscle in Hu sheep. Multi-omic profiling of postnatal muscle development in Hu sheep from 3 days to 12 months of age highlights the epigenetic factors involved in regulating skeletal muscle growth.
DOI	10.1038/s42003-023-05439-0
关键词[WOS]	MYOGENIC REGULATORY FACTORS ; SATELLITE CELLS ; TRANSCRIPTION FACTORS ; METHYLATION ; PACKAGE ; BIOGENESIS ; ALIGNMENT ; ENOLASE ; ALPHA ; MYOD
收录类别	SCI
语种	英语
资助项目	This work was supported by the National Key Ramp;D Program of China (2021YFD1300901) and the National Science Foundation of China (32172683).[2021YFD1300901] ; National Key Ramp;D Program of China[32172683] ; National Science Foundation of China
项目资助者	This work was supported by the National Key Ramp;D Program of China (2021YFD1300901) and the National Science Foundation of China (32172683). ; National Key Ramp;D Program of China ; National Science Foundation of China
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS类目	Biology ; Multidisciplinary Sciences
WOS记录号	WOS:001095842600002
出版者	NATURE PORTFOLIO
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/54398
专题	中科院工业视觉智能装备工程实验室中科院工业视觉智能装备工程实验室_精密感知与控制
通讯作者	Han, Hongbing
作者单位	1.China Agr Univ, Coll Anim Sci & Technol, Beijing Key Lab Anim Genet Improvement, Beijing, Peoples R China 2.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Beijing, Peoples R China 3.China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs, Beijing, Peoples R China 4.Tianjin Key Lab Anim Mol Breeding & Biotechnol, Tianjin, Peoples R China 5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 6.China Agr Univ, Frontiers Sci Ctr Mol Design Breeding MOE, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Cao, Yutao,Ai, Yue,Zhang, Xiaosheng,et al. Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep[J]. COMMUNICATIONS BIOLOGY,2023,6(1):20.
APA	Cao, Yutao.,Ai, Yue.,Zhang, Xiaosheng.,Zhang, Jinlong.,Long, Xianlei.,...&Han, Hongbing.(2023).Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep.COMMUNICATIONS BIOLOGY,6(1),20.
MLA	Cao, Yutao,et al."Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep".COMMUNICATIONS BIOLOGY 6.1(2023):20.