Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices

doi:10.1002/advs.202303491

	Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices
	Li, Deling 1,2,3; Shi, Hui 2,3,4,5,6; Qi, Qingrong 2,3,7; Chang, Baisong 2,3,8; Jiang, Yuanwen 9; Qian, Kun 4; Guan, Xiudong 1; Kang, Peng 1; Ma, Ning 10; Zhang, Yuan1 ; Zhang, Zeyu11 ; Shi, Xiaojing11,12 ; Qu, Chunrong 4; Wu, Yilei 9; Chen, Weiyu 2,3; Chen, Hao4 ; Li, Baowang 1; Chen, Liangpeng 1; Li, Ziyang 1; Ma, Shunchang 1; Xu, Lingyun 2,3; Zhang, Yanrong 2,3; Tian, Jie 11,12,13; Hu, Zhenhua11,12 ; Jia, Wang 1; Cheng, Zhen 2,3,4,5
发表期刊	ADVANCED SCIENCE
	2023-11-09
页码	13
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Jia, Wang(jiawang@bjtth.org) ; Cheng, Zhen(zcheng@simm.ac.cn)
摘要	Medical devices are commonly implanted underneath the skin, but how to real-time noninvasively monitor their migration, integrity, and biodegradation in human body is still a formidable challenge. Here, the study demonstrates that benzyl violet 4B (BV-4B), a main component in the FDA-approved surgical suture, is found to produce fluorescence signal in the first near-infrared window (NIR-I, 700-900 nm) in polar solutions, whereas BV-4B self-assembles into highly crystalline aggregates upon a formation of ultrasmall nanodots and can emit strong fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm) with a dramatic bathochromic shift in the absorption spectrum of approximate to 200 nm. Intriguingly, BV-4B-involved suture knots underneath the skin can be facilely monitored during the whole degradation process in vivo, and the rupture of the customized BV-4B-coated silicone catheter is noninvasively diagnosed by NIR-II imaging. Furthermore, BV-4B suspended in embolization glue achieves hybrid fluorescence-guided surgery (hybrid FGS) for arteriovenous malformation. As a proof-of-concept study, the solid-state BV-4B is successfully used for NIR-II imaging of surgical sutures in operations of patients. Overall, as a clinically translatable solid-state dye, BV-4B can be applied for in vivo monitoring the fate of medical devices by NIR-II imaging. Benzyl Violet 4B (BV-4B), serving as a component in the FDA-approved surgical sutures, is first discovered as a novel solid-state dye in the NIR-II window (1000-1700 nm). It can be used to non-invasively monitor the degradation process of surgical sutures, to diagnose the rupture of BV-4B-coated silicone catheter and to guide the hybrid fluorescence-guided surgery (hybrid FGS) of arteriovenous malformation (AVM) with embolization glue.image
关键词	aggregates in vivo imaging medical devices NIR-II fluorescence
DOI	10.1002/advs.202303491
关键词[WOS]	EMBOLIZATION
收录类别	SCI
语种	英语
资助项目	Part of this work was performed at the Stanford Nano Shared Facilities (SNSF), supported by the National Science Foundation under award ECCS-1542152. The authors appreciated Qiang Liu for measuring the absolute quantum yield of BV-4B powder, as well as HOR[ECCS-1542152] ; National Science Foundation ; HORIBA application specialist Ren Wanqing[81971668] ; HORIBA application specialist Ren Wanqing[82222034] ; HORIBA application specialist Ren Wanqing[U2267221] ; HORIBA application specialist Ren Wanqing[62027901] ; HORIBA application specialist Ren Wanqing[81930053] ; HORIBA application specialist Ren Wanqing[92059207] ; HORIBA application specialist Ren Wanqing[81227901] ; National Natural Science Foundation of China (NSFC)[2017YFA0205200] ; National Key Research and Development Program of China[TM202301H003] ; Shanghai Municipal Science and Technology Major Project[xx2017017] ; Beijing Nova Program[JCTD-2021-08] ; Beijing Talents Foundation, CAS Youth Interdisciplinary Team[JQ19027] ; Beijing Natural Science Foundation[HLHPTP201703] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[YSP201902] ; Clinical Scientist Supporting grant of Beijing Tiantan Hospital ; Radiology Department at Stanford University[201906080019] ; China Scholarship Council
项目资助者	Part of this work was performed at the Stanford Nano Shared Facilities (SNSF), supported by the National Science Foundation under award ECCS-1542152. The authors appreciated Qiang Liu for measuring the absolute quantum yield of BV-4B powder, as well as HOR ; National Science Foundation ; HORIBA application specialist Ren Wanqing ; National Natural Science Foundation of China (NSFC) ; National Key Research and Development Program of China ; Shanghai Municipal Science and Technology Major Project ; Beijing Nova Program ; Beijing Talents Foundation, CAS Youth Interdisciplinary Team ; Beijing Natural Science Foundation ; Zhuhai High-level Health Personnel Team Project (Zhuhai) ; Clinical Scientist Supporting grant of Beijing Tiantan Hospital ; Radiology Department at Stanford University ; China Scholarship Council
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:001099155600001
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/54476
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Hu, Zhenhua; Jia, Wang; Cheng, Zhen
作者单位	1.Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurosurg,Beijing Neurosurg Inst, Beijing 100070, Peoples R China 2.Stanford Univ, Bio X Program, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA 3.Stanford Univ, Dept Radiol, Stanford, CA 94305 USA 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 6.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, Shenyang 110000, Peoples R China 7.Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China 8.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 9.Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA 10.Capital Med Univ, Beijing Tiantan Hosp, Intervent Neuroradiol Ctr, Beijing 100070, Peoples R China 11.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China 12.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 13.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Li, Deling,Shi, Hui,Qi, Qingrong,et al. Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices[J]. ADVANCED SCIENCE,2023:13.
APA	Li, Deling.,Shi, Hui.,Qi, Qingrong.,Chang, Baisong.,Jiang, Yuanwen.,...&Cheng, Zhen.(2023).Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices.ADVANCED SCIENCE,13.
MLA	Li, Deling,et al."Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices".ADVANCED SCIENCE (2023):13.