Transverse MNP Signal-Based Isotropic Imaging for Magnetic Particle Imaging

doi:10.1109/TIM.2023.3341123

	Transverse MNP Signal-Based Isotropic Imaging for Magnetic Particle Imaging
	Li, Lei1 ; Liao, Yidong 1; Wang, Qibin 1; Zhang, Zhonghao 1; Ge, Dawei 1; Hu, Jiawei 1; He, Ning 1; Liu, Yanjun2 ; Xu, Chenxiao 1; Gao, Yunpeng 1; Guo, Pengyue 1; Hui, Hui3,4,5 ; Feng, Xin3,4,5 ; Zhu, Shouping 1; Tian, Jie 1,3,4,5,6,7
发表期刊	IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
ISSN	0018-9456
	2024
卷号	73 页码:13
通讯作者	Feng, Xin(xin.feng@ia.ac.cn) ; Zhu, Shouping(spzhu@xidian.edu.cn) ; Tian, Jie(tian@ieee.org)
摘要	Magnetic particle imaging (MPI) is a tracer-based imaging modality known for its high sensitivity and temporal resolution. It makes the quantitative visualization of the concentration and spatial location of magnetic nanoparticles (MNPs) possible. The x-space method is widely used in MPI for high-speed image reconstruction. In this method, the received signal is mapped directly onto the corresponding spatial position. However, the anisotropic 2-D point spread function (PSF) in the x-space method introduces artifacts and blur in the reconstructed images. In this study, an isotropic MPI method, transverse MNP signal-based isotropic imaging (TSI), was developed. It makes isotropic imaging possible in 2-D unidirectional Cartesian MPI. Unlike conventional methods that rely on MNP signals registered from the same direction as the excitation, TSI only utilizes MNP signals received perpendicular to the excitation direction. In TSI, the velocity of the time domain signal is first normalized to obtain a "raw-image." The raw-image is then integrated, differentiated, and added to generate an isotropic MPI image. Because all the operations in TSI are analytical, it preserves the real-time imaging characteristics of the x-space while isotropic imaging is performed. The PSF of TSI was calculated through analytical derivation and the resolution isotropy was validated through simulation and imaging experiments on an in-house-built MPI system. The simulation and experimental results demonstrate that, by improving the isotropy, TSI achieves an approximately 2.5- x increase in resolution in the nonexcitation direction compared with the conventional x-space method. The proposed TSI algorithm does not increase hardware complexity and requires only half the scanning time of the previously proposed multichannel method. In addition, the transverse MNP signal used in TSI is geometrically decoupled from the excitation magnetic field, eliminating the need for a special compensation design for the receiving coils. This shows promise for future MPI designs with flexible surface coils.
关键词	Isotropic resolution magnetic particle imaging (MPI) reconstruction transverse magnetic nanoparticle (MNP) signal
DOI	10.1109/TIM.2023.3341123
关键词[WOS]	RELAXATION ; TRACKING ; SYSTEM
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China
项目资助者	National Natural Science Foundation of China
WOS研究方向	Engineering ; Instruments & Instrumentation
WOS类目	Engineering, Electrical & Electronic ; Instruments & Instrumentation
WOS记录号	WOS:001136737400008
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/55426
专题	中国科学院分子影像重点实验室
通讯作者	Feng, Xin; Zhu, Shouping; Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Peoples R China 2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China 3.Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Inst Automat, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100080, Peoples R China 6.Beihang Univ, Sch Engn Med, Sch Biol Sci & Med Engn, Key Lab Big Data Based Precis Med, Beijing 100191, Peoples R China 7.Beihang Univ, Minist Ind & Informat Technol China, Beijing 100191, Peoples R China
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Li, Lei,Liao, Yidong,Wang, Qibin,et al. Transverse MNP Signal-Based Isotropic Imaging for Magnetic Particle Imaging[J]. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT,2024,73:13.
APA	Li, Lei.,Liao, Yidong.,Wang, Qibin.,Zhang, Zhonghao.,Ge, Dawei.,...&Tian, Jie.(2024).Transverse MNP Signal-Based Isotropic Imaging for Magnetic Particle Imaging.IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT,73,13.
MLA	Li, Lei,et al."Transverse MNP Signal-Based Isotropic Imaging for Magnetic Particle Imaging".IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT 73(2024):13.