Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection | |
Chao Li1; Changjian Li2,3; jian Zhou1; Yueqi Wang4; Hainan Wu,1; Luzheng Xu1; Yifeng Li2,3; Xizhao Sui1; Guanchao Jiang1; Yun Li1; Zhenhua Hu4; Jie Tian2,3,4; Fan Yang1,5 | |
发表期刊 | MOLECULAR PHARMACEUTICS |
ISSN | 1543-8384 |
2024-04-30 | |
页码 | 1543-8392 |
通讯作者 | Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Yang, Fan(yangfan@pkuph.edu.cn) |
摘要 | There has been an increase in the use of molecular probe diagnostic techniques for lung cancer, and magnetic resonance imaging (MRI) offers specific advantages for diagnosing pulmonary carcinoma. Furthermore, advancements in near-infrared II (NIR-II) fluorescence have provided a new method for precise intraoperative tumor resection. However, few probes combine preoperative diagnosis with intraoperative imaging. This study aims to fill this research void by employing a dual-modal probe that targets the epidermal growth factor receptor for MR and NIR-II imaging, enabling the preoperative diagnosis of lung cancer using MRI and precise intraoperative tumor localization using NIR-II with a single probe. The imaging effects and targeting ability of the probe were confirmed in cell lines, mouse models, and clinical samples. The MR signal decreased within 24 h in the patient-derived xenograft mouse model. The average signal-to-background ratio of NIR-II reached 3.98 ± 0.27. The clinical sample also showed a decrease in the T2 signal using MRI, and the NIR-II optical signal-to-background ratio was 3.29. It is expected that this probe can improve the diagnostic rate of lung cancer using MRI and enable precise intraoperative tumor resection using NIR-II. |
关键词 | lung cancer magnetic resonance imaging epidermalgrowth factor receptor surgery near-infrared two-zone |
DOI | 10.1021/acs.molpharmaceut.3c01137 |
关键词[WOS] | CONTRAST AGENTS ; POOR-PROGNOSIS ; EXPRESSION |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
WOS记录号 | WOS:001240728700001 |
出版者 | AMER CHEMICAL SOC |
七大方向——子方向分类 | 医学影像处理与分析 |
国重实验室规划方向分类 | 其他 |
是否有论文关联数据集需要存交 | 否 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/57353 |
专题 | 中国科学院分子影像重点实验室 |
作者单位 | 1.Peking University People's Hospital 2.School of Engineering Medicine, Beihang University 3.Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology 4.CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences 5.Peking University Medical and Health Analysis Center |
推荐引用方式 GB/T 7714 | Chao Li,Changjian Li,jian Zhou,et al. Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection[J]. MOLECULAR PHARMACEUTICS,2024:1543-8392. |
APA | Chao Li.,Changjian Li.,jian Zhou.,Yueqi Wang.,Hainan Wu,.,...&Fan Yang.(2024).Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection.MOLECULAR PHARMACEUTICS,1543-8392. |
MLA | Chao Li,et al."Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection".MOLECULAR PHARMACEUTICS (2024):1543-8392. |
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