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Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis
Zhou, Bo1; Yao, Hongxiang2; Wang, Pan1; Zhang, Zengqiang1,3; Zhan, Yafeng4,5; Ma, Jianhua5; Xu, Kaibin4,6; Wang, Luning1; An, Ningyu2; Liu, Yong4,6; Zhang, Xi1
2015
发表期刊BIOMED RESEARCH INTERNATIONAL
文章类型Article
摘要The purpose of our study was to investigate whether the whole-brain functional connectivity pattern exhibits disease severity-related alterations in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Resting-state functional magnetic resonance imaging data were acquired in 27 MCI subjects, 35 AD patients, and 27 age-and gender-matched subjects with normal cognition (NC). Interregional functional connectivity was assessed based on a predefined template which parcellated the brain into 90 regions. Altered whole-brain functional connectivity patterns were identified via connectivity comparisons between the AD and NC subjects. Finally, the relationship between functional connectivity strength and cognitive ability according to the mini-mental state examination (MMSE) was evaluated in the MCI and AD groups. Compared with the NC group, the AD group exhibited decreased functional connectivities throughout the brain. The most significantly affected regions included several important nodes of the default mode network and the temporal lobe. Moreover, changes in functional connectivity strength exhibited significant associations with disease severity-related alterations in the AD and MCI groups. The present study provides novel evidence and will facilitate meta-analysis of whole-brain analyses in AD and MCI, which will be critical to better understand the neural basis of AD.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RESTING-STATE FMRI ; DEFAULT-MODE NETWORK ; MEDIAL TEMPORAL-LOBE ; DISCONNECTION SYNDROME ; EPISODIC MEMORY ; CORTICAL HUBS ; INDIVIDUALS ; FREQUENCY ; THALAMUS ; CORTEX
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS类目Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS记录号WOS:000356685000001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/7918
专题脑网络组研究中心
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Bo,Yao, Hongxiang,Wang, Pan,et al. Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Zhou, Bo.,Yao, Hongxiang.,Wang, Pan.,Zhang, Zengqiang.,Zhan, Yafeng.,...&Zhang, Xi.(2015).Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis.BIOMED RESEARCH INTERNATIONAL.
MLA Zhou, Bo,et al."Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis".BIOMED RESEARCH INTERNATIONAL (2015).
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