CASIA OpenIR  > 脑网络组研究中心
Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis
Zhou, Bo1; Yao, Hongxiang2; Wang, Pan1; Zhang, Zengqiang1,3; Zhan, Yafeng4,5; Ma, Jianhua5; Xu, Kaibin4,6; Wang, Luning1; An, Ningyu2; Liu, Yong4,6; Zhang, Xi1
Source PublicationBIOMED RESEARCH INTERNATIONAL
2015
SubtypeArticle
AbstractThe purpose of our study was to investigate whether the whole-brain functional connectivity pattern exhibits disease severity-related alterations in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Resting-state functional magnetic resonance imaging data were acquired in 27 MCI subjects, 35 AD patients, and 27 age-and gender-matched subjects with normal cognition (NC). Interregional functional connectivity was assessed based on a predefined template which parcellated the brain into 90 regions. Altered whole-brain functional connectivity patterns were identified via connectivity comparisons between the AD and NC subjects. Finally, the relationship between functional connectivity strength and cognitive ability according to the mini-mental state examination (MMSE) was evaluated in the MCI and AD groups. Compared with the NC group, the AD group exhibited decreased functional connectivities throughout the brain. The most significantly affected regions included several important nodes of the default mode network and the temporal lobe. Moreover, changes in functional connectivity strength exhibited significant associations with disease severity-related alterations in the AD and MCI groups. The present study provides novel evidence and will facilitate meta-analysis of whole-brain analyses in AD and MCI, which will be critical to better understand the neural basis of AD.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordRESTING-STATE FMRI ; DEFAULT-MODE NETWORK ; MEDIAL TEMPORAL-LOBE ; DISCONNECTION SYNDROME ; EPISODIC MEMORY ; CORTICAL HUBS ; INDIVIDUALS ; FREQUENCY ; THALAMUS ; CORTEX
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000356685000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/7918
Collection脑网络组研究中心
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Bo,Yao, Hongxiang,Wang, Pan,et al. Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Zhou, Bo.,Yao, Hongxiang.,Wang, Pan.,Zhang, Zengqiang.,Zhan, Yafeng.,...&Zhang, Xi.(2015).Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis.BIOMED RESEARCH INTERNATIONAL.
MLA Zhou, Bo,et al."Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis".BIOMED RESEARCH INTERNATIONAL (2015).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Bo]'s Articles
[Yao, Hongxiang]'s Articles
[Wang, Pan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Bo]'s Articles
[Yao, Hongxiang]'s Articles
[Wang, Pan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Bo]'s Articles
[Yao, Hongxiang]'s Articles
[Wang, Pan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.