CASIA OpenIR  > 09年以前成果
Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality
Zang, YF; Jin, Z; Weng, XC; Zhang, L; Zeng, YW; Yang, L; Wang, YF; Seidman, LJ; Faraone, SV
Source PublicationBRAIN & DEVELOPMENT
2005-12-01
Volume27Issue:8Pages:544-550
SubtypeArticle
AbstractUsing event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks. (c) 2005 Elsevier B.V. All rights reserved.
KeywordAttention-deficit Hyperactivity Disorder Functional Magnetic Resonance Imaging Stroop Effect Hypofrontality Methylphenidate Compensation
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordBASAL GANGLIA VOLUMES ; MAGNETIC-RESONANCE ; DEFICIT/HYPERACTIVITY DISORDER ; CEREBELLAR ; CHILDREN ; METHYLPHENIDATE ; ADHD ; SCHIZOPHRENIA ; RELAXOMETRY ; ADOLESCENTS
Indexed BySCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000234199200002
Citation statistics
Cited Times:103[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9115
Collection09年以前成果
Affiliation1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.306 Hosp, Dept MRI, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
4.Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA
5.Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
6.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
7.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China
Recommended Citation
GB/T 7714
Zang, YF,Jin, Z,Weng, XC,et al. Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality[J]. BRAIN & DEVELOPMENT,2005,27(8):544-550.
APA Zang, YF.,Jin, Z.,Weng, XC.,Zhang, L.,Zeng, YW.,...&Faraone, SV.(2005).Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality.BRAIN & DEVELOPMENT,27(8),544-550.
MLA Zang, YF,et al."Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality".BRAIN & DEVELOPMENT 27.8(2005):544-550.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zang, YF]'s Articles
[Jin, Z]'s Articles
[Weng, XC]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zang, YF]'s Articles
[Jin, Z]'s Articles
[Weng, XC]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zang, YF]'s Articles
[Jin, Z]'s Articles
[Weng, XC]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.