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White matter tract integrity and intelligence in patients with mental retardation and healthy adults
Yu, Chunshui1,2; Li, Jun3; Liu, Yong3; Qin, Wen1,2; Li, Yonghui3; Shu, Ni; Jiang, Tianzi3; Li, Kuncheng1,2
Source PublicationNEUROIMAGE
2008-05-01
Volume40Issue:4Pages:1533-1541
SubtypeArticle
AbstractIt is well known that brain structures correlate with intelligence but the association between the integrity of brain white matter tracts and intelligence in patients with mental retardation (MR) and healthy adults remains unknown. The aims of this study are to investigate whether the integrity of corpus callosum ( CC), cingulum, uncinate fasciculus (UF), optic radiation ( OR) and corticospinal tract (CST) are damaged in patients with MR, and to determine the correlations between the integrity of these tracts and full scale intelligence quotient (FSIQ) in both patients and controls. Fifteen MR patients and 79 healthy controls underwent intelligence tests and diffusion tensor imaging examinations. According to the FSIQ, all healthy controls were divided into general intelligence (GI: FSIQ < 120; n = 42) and high intelligence ( HI: FSIQ >= 120; n = 37) groups. Intelligence was assessed by Chinese Revised Wechsler Adult Intelligence Scale, and white matter tract integrity was assessed by fractional anisotropy ( FA). MR patients showed significantly lower FA than healthy controls in the CC, UF, OR and CST. However, GI subjects only demonstrated lower FA than HI subjects in the right UF. Partial correlation analysis controlling for age and sex showed that FSIQ scores were significantly correlated with the FA of the bilateral UF, genu and truncus of CC, bilateral OR and left CST. While FSIQ scores were only significantly correlated with the FA of the right UF when further controlling for group. This study indicate that MR patients show extensive damage in the integrity of the brain white matter tracts, and the right UF is an important neural basis of human intelligence. (c) 2008 Elsevier Inc. All rights reserved.
KeywordDiffusion Tensor Imaging Tractography Fractional Anisotropy Mental Retardation Intelligence
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDIFFUSION TENSOR MRI ; NORMAL PEDIATRIC POPULATION ; GENERAL INTELLIGENCE ; HUMAN BRAIN ; INTELLECTUAL DISABILITY ; CORTICOSPINAL TRACT ; VISUAL IMPAIRMENT ; PYRAMIDAL TRACT ; HEAD SIZE ; CHILDREN
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000255347100010
Citation statistics
Cited Times:73[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9612
Collection09年以前成果
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
2.Edu Minist, Key Lab Neurodegenerat Dis, Beijing 100053, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recog, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yu, Chunshui,Li, Jun,Liu, Yong,et al. White matter tract integrity and intelligence in patients with mental retardation and healthy adults[J]. NEUROIMAGE,2008,40(4):1533-1541.
APA Yu, Chunshui.,Li, Jun.,Liu, Yong.,Qin, Wen.,Li, Yonghui.,...&Li, Kuncheng.(2008).White matter tract integrity and intelligence in patients with mental retardation and healthy adults.NEUROIMAGE,40(4),1533-1541.
MLA Yu, Chunshui,et al."White matter tract integrity and intelligence in patients with mental retardation and healthy adults".NEUROIMAGE 40.4(2008):1533-1541.
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