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Altered functional connectivity of primary visual cortex in early blindness
Yu, Chunshui2; Liu, Yong1; Li, Jun1; Zhou, Yuan1; Wang, Kun1; Tian, Lixia1; Qin, Wen2; Jiang, Tianzi1; Li, Kuncheng2
发表期刊HUMAN BRAIN MAPPING
2008-05-01
卷号29期号:5页码:533-543
文章类型Article
摘要In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the functional connectivity between the PVA and other brain areas in resting state. The purpose of this study is to investigate the differences in the functional connectivity of the PVA between early blind and sighted subjects using resting functional MRI data. The altered functional connectivity was identified by comparing the correlation coefficients of the PVA with other brain areas between 16 early blind subjects (blindness onset within I year of age) and 32 gender- and age-matched healthy sighted volunteers. Compared with the sighted, the early blind subjects showed decreased functional connectivity between the left PVA and the bilateral supplementary motor area (SMA), pre- and postcentral gyri, superior parietal lobule, and the left superior and middle temporal gyri. Early blind subjects also showed decreased functional connectivity between the right PVA and the bilateral SMA, pre- and postcentral gyri. Our findings suggest that early deprivation of a single sensory modality induces alterations of functional connectivity between the deprived functional area and other associated brain areas.
关键词Human Brain Early Blindness Resting State Functional Connectivity Primary Visual Area Functional Magnetic Resonance Imaging
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RESTING-STATE ; CONGENITALLY BLIND ; HUMAN BRAIN ; SIGHTED INDIVIDUALS ; ACTIVATION PATTERNS ; ALZHEIMERS-DISEASE ; NETWORK ANALYSIS ; ADAPTIVE-CHANGES ; MENTAL-IMAGERY ; MOTOR CORTEX
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000255673900004
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9698
专题09年以前成果
作者单位1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
2.Capital Univ Med Sci, Dept Radiol, Xuanwu Hosp, Beijing, Peoples R China
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GB/T 7714
Yu, Chunshui,Liu, Yong,Li, Jun,et al. Altered functional connectivity of primary visual cortex in early blindness[J]. HUMAN BRAIN MAPPING,2008,29(5):533-543.
APA Yu, Chunshui.,Liu, Yong.,Li, Jun.,Zhou, Yuan.,Wang, Kun.,...&Li, Kuncheng.(2008).Altered functional connectivity of primary visual cortex in early blindness.HUMAN BRAIN MAPPING,29(5),533-543.
MLA Yu, Chunshui,et al."Altered functional connectivity of primary visual cortex in early blindness".HUMAN BRAIN MAPPING 29.5(2008):533-543.
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