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Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI | |
Li, XF; Tian, J; Li, EZ; Wang, XX; Dai, JP; Ai, L; Tian, Jie | |
发表期刊 | MAGNETIC RESONANCE IMAGING |
2003-06-01 | |
卷号 | 21期号:5页码:503-510 |
文章类型 | Article |
摘要 | Absolute quantification of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (NITT) are of great relevance for clinical applications. One of the widely used methods for quantification of these parameters is gamma-variate fitting. Traditional nonlinear regression methods for gamma-variate fitting are inaccurate and computationally demanding. In this study, we developed an adaptive total least square method (ATSSL) to fit a gamma-variate function to the delayed concentration-time course. For each concentration-time curve, the beginning and ending time point of the curve are adaptively determined online. After the curves were fitted, a robust method for automatically determination of arterial input function (AIF) from whole and region of interest (ROI) was developed. Using the obtained AIF and fitted gamma-variate concentration-time curve, the MTT, CBV, and CBF were calculated by utilizing singular value decomposition algorithm. Computer simulations show that the suggested method is adaptive, reliable, and insensitive to noise. Comparison with the traditional nonlinear regression method indicated that the presented method is more accurate and faster to determine the CBV, CBF and NITT. (C) 2003 Elsevier Inc. All rights reserved. |
关键词 | Arterial Input Function Mean Transit Time Adaptive Total Linear Least Square Concentration-time Curves Blood Flow |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | CEREBRAL BLOOD-FLOW ; HIGH-RESOLUTION MEASUREMENT ; TRACER BOLUS PASSAGES ; SIGNAL-TO-NOISE ; GAMMA-VARIATE ; VOLUME |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000184394000007 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/9890 |
专题 | 09年以前成果 |
通讯作者 | Tian, Jie |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing, Peoples R China 2.Tian Tan Hosp, Dept Radiol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, XF,Tian, J,Li, EZ,et al. Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI[J]. MAGNETIC RESONANCE IMAGING,2003,21(5):503-510. |
APA | Li, XF.,Tian, J.,Li, EZ.,Wang, XX.,Dai, JP.,...&Tian, Jie.(2003).Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI.MAGNETIC RESONANCE IMAGING,21(5),503-510. |
MLA | Li, XF,et al."Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI".MAGNETIC RESONANCE IMAGING 21.5(2003):503-510. |
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