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Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI
Li, XF; Tian, J; Li, EZ; Wang, XX; Dai, JP; Ai, L; Tian, Jie
Source PublicationMAGNETIC RESONANCE IMAGING
2003-06-01
Volume21Issue:5Pages:503-510
SubtypeArticle
AbstractAbsolute quantification of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (NITT) are of great relevance for clinical applications. One of the widely used methods for quantification of these parameters is gamma-variate fitting. Traditional nonlinear regression methods for gamma-variate fitting are inaccurate and computationally demanding. In this study, we developed an adaptive total least square method (ATSSL) to fit a gamma-variate function to the delayed concentration-time course. For each concentration-time curve, the beginning and ending time point of the curve are adaptively determined online. After the curves were fitted, a robust method for automatically determination of arterial input function (AIF) from whole and region of interest (ROI) was developed. Using the obtained AIF and fitted gamma-variate concentration-time curve, the MTT, CBV, and CBF were calculated by utilizing singular value decomposition algorithm. Computer simulations show that the suggested method is adaptive, reliable, and insensitive to noise. Comparison with the traditional nonlinear regression method indicated that the presented method is more accurate and faster to determine the CBV, CBF and NITT. (C) 2003 Elsevier Inc. All rights reserved.
KeywordArterial Input Function Mean Transit Time Adaptive Total Linear Least Square Concentration-time Curves Blood Flow
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCEREBRAL BLOOD-FLOW ; HIGH-RESOLUTION MEASUREMENT ; TRACER BOLUS PASSAGES ; SIGNAL-TO-NOISE ; GAMMA-VARIATE ; VOLUME
Indexed BySCI
Language英语
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000184394000007
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9890
Collection09年以前成果
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing, Peoples R China
2.Tian Tan Hosp, Dept Radiol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, XF,Tian, J,Li, EZ,et al. Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI[J]. MAGNETIC RESONANCE IMAGING,2003,21(5):503-510.
APA Li, XF.,Tian, J.,Li, EZ.,Wang, XX.,Dai, JP.,...&Tian, Jie.(2003).Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI.MAGNETIC RESONANCE IMAGING,21(5),503-510.
MLA Li, XF,et al."Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI".MAGNETIC RESONANCE IMAGING 21.5(2003):503-510.
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