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Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI
Li, XF; Tian, J; Li, EZ; Wang, XX; Dai, JP; Ai, L; Tian, Jie
2003-06-01
发表期刊MAGNETIC RESONANCE IMAGING
卷号21期号:5页码:503-510
文章类型Article
摘要Absolute quantification of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (NITT) are of great relevance for clinical applications. One of the widely used methods for quantification of these parameters is gamma-variate fitting. Traditional nonlinear regression methods for gamma-variate fitting are inaccurate and computationally demanding. In this study, we developed an adaptive total least square method (ATSSL) to fit a gamma-variate function to the delayed concentration-time course. For each concentration-time curve, the beginning and ending time point of the curve are adaptively determined online. After the curves were fitted, a robust method for automatically determination of arterial input function (AIF) from whole and region of interest (ROI) was developed. Using the obtained AIF and fitted gamma-variate concentration-time curve, the MTT, CBV, and CBF were calculated by utilizing singular value decomposition algorithm. Computer simulations show that the suggested method is adaptive, reliable, and insensitive to noise. Comparison with the traditional nonlinear regression method indicated that the presented method is more accurate and faster to determine the CBV, CBF and NITT. (C) 2003 Elsevier Inc. All rights reserved.
关键词Arterial Input Function Mean Transit Time Adaptive Total Linear Least Square Concentration-time Curves Blood Flow
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CEREBRAL BLOOD-FLOW ; HIGH-RESOLUTION MEASUREMENT ; TRACER BOLUS PASSAGES ; SIGNAL-TO-NOISE ; GAMMA-VARIATE ; VOLUME
收录类别SCI
语种英语
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
WOS类目Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000184394000007
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9890
专题09年以前成果
通讯作者Tian, Jie
作者单位1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing, Peoples R China
2.Tian Tan Hosp, Dept Radiol, Beijing, Peoples R China
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GB/T 7714
Li, XF,Tian, J,Li, EZ,et al. Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI[J]. MAGNETIC RESONANCE IMAGING,2003,21(5):503-510.
APA Li, XF.,Tian, J.,Li, EZ.,Wang, XX.,Dai, JP.,...&Tian, Jie.(2003).Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI.MAGNETIC RESONANCE IMAGING,21(5),503-510.
MLA Li, XF,et al."Adaptive total linear least square method for quantification of mean transit time in brain perfusion MRI".MAGNETIC RESONANCE IMAGING 21.5(2003):503-510.
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