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Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green
Fang, Cheng1,2; Wang, Kun2,3; Zeng, Chaoting1; Chi, Chongwei2,3; Shang, Wenting2; Ye, Jinzuo2; Mao, Yamin2; Fan, Yingfang1; Yang, Jian1; Xiang, Nan1; Zeng, Ning1; Zhu, Wen1; Fang, Chihua1; Tian, Jie2,3
2016-02-11
发表期刊SCIENTIFIC REPORTS
卷号6期号:21013页码:-
文章类型Article
摘要Tissue necrosis commonly accompanies the development of a wide range of serious diseases. Therefore, highly sensitive detection and precise boundary delineation of necrotic tissue via effective imaging techniques are crucial for clinical treatments; however, no imaging modalities have achieved satisfactory results to date. Although fluorescence molecular imaging (FMI) shows potential in this regard, no effective necrosis-avid fluorescent probe has been developed for clinical applications. Here, we demonstrate that indocyanine green (ICG) can achieve high avidity of necrotic tissue owing to its interaction with lipoprotein (LP) and phospholipids. The mechanism was explored at the cellular and molecular levels through a series of in vitro studies. Detection of necrotic tissue and real-time image-guided surgery were successfully achieved in different organs of different animal models with the help of FMI using in house-designed imaging devices. The results indicated that necrotic tissue with a 0.6 mm diameter could be effectively detected with precise boundary definition. We believe that the new discovery and the associated imaging techniques will improve personalized and precise surgery in the near future.
关键词-
WOS标题词Science & Technology
DOI10.1038/srep21013
关键词[WOS]IN-VIVO ; ACUTE-PANCREATITIS ; CONTRAST AGENTS ; CANCER-SURGERY ; OVARIAN-CANCER ; BREAST-CANCER ; LASER-LIGHT ; ANGIOGRAPHY ; HYPERICIN ; PROTEIN
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2011CB707700) ; National Natural Science Foundation of China(81227901 ; Open Projects Program of Key Laboratory of Molecular Imaging(Y3SA011x48) ; Equipment research & development project(YZ201164) ; 61231004 ; U1401254)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000369924700001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11344
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Fang, Cheng,Wang, Kun,Zeng, Chaoting,et al. Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green[J]. SCIENTIFIC REPORTS,2016,6(21013):-.
APA Fang, Cheng.,Wang, Kun.,Zeng, Chaoting.,Chi, Chongwei.,Shang, Wenting.,...&Tian, Jie.(2016).Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green.SCIENTIFIC REPORTS,6(21013),-.
MLA Fang, Cheng,et al."Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green".SCIENTIFIC REPORTS 6.21013(2016):-.
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