CASIA OpenIR  > 中国科学院分子影像重点实验室
Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green
Fang, Cheng1,2; Wang, Kun2,3; Zeng, Chaoting1; Chi, Chongwei2,3; Shang, Wenting2; Ye, Jinzuo2; Mao, Yamin2; Fan, Yingfang1; Yang, Jian1; Xiang, Nan1; Zeng, Ning1; Zhu, Wen1; Fang, Chihua1; Tian, Jie2,3
Source PublicationSCIENTIFIC REPORTS
2016-02-11
Volume6Issue:21013Pages:-
SubtypeArticle
AbstractTissue necrosis commonly accompanies the development of a wide range of serious diseases. Therefore, highly sensitive detection and precise boundary delineation of necrotic tissue via effective imaging techniques are crucial for clinical treatments; however, no imaging modalities have achieved satisfactory results to date. Although fluorescence molecular imaging (FMI) shows potential in this regard, no effective necrosis-avid fluorescent probe has been developed for clinical applications. Here, we demonstrate that indocyanine green (ICG) can achieve high avidity of necrotic tissue owing to its interaction with lipoprotein (LP) and phospholipids. The mechanism was explored at the cellular and molecular levels through a series of in vitro studies. Detection of necrotic tissue and real-time image-guided surgery were successfully achieved in different organs of different animal models with the help of FMI using in house-designed imaging devices. The results indicated that necrotic tissue with a 0.6 mm diameter could be effectively detected with precise boundary definition. We believe that the new discovery and the associated imaging techniques will improve personalized and precise surgery in the near future.
Keyword-
WOS HeadingsScience & Technology
DOI10.1038/srep21013
WOS KeywordIN-VIVO ; ACUTE-PANCREATITIS ; CONTRAST AGENTS ; CANCER-SURGERY ; OVARIAN-CANCER ; BREAST-CANCER ; LASER-LIGHT ; ANGIOGRAPHY ; HYPERICIN ; PROTEIN
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 Program)(2011CB707700) ; National Natural Science Foundation of China(81227901 ; Open Projects Program of Key Laboratory of Molecular Imaging(Y3SA011x48) ; Equipment research & development project(YZ201164) ; 61231004 ; U1401254)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000369924700001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11344
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Fang, Cheng,Wang, Kun,Zeng, Chaoting,et al. Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green[J]. SCIENTIFIC REPORTS,2016,6(21013):-.
APA Fang, Cheng.,Wang, Kun.,Zeng, Chaoting.,Chi, Chongwei.,Shang, Wenting.,...&Tian, Jie.(2016).Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green.SCIENTIFIC REPORTS,6(21013),-.
MLA Fang, Cheng,et al."Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green".SCIENTIFIC REPORTS 6.21013(2016):-.
Files in This Item: Download All
File Name/Size DocType Version Access License
srep21013.pdf(1878KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Fang, Cheng]'s Articles
[Wang, Kun]'s Articles
[Zeng, Chaoting]'s Articles
Baidu academic
Similar articles in Baidu academic
[Fang, Cheng]'s Articles
[Wang, Kun]'s Articles
[Zeng, Chaoting]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Fang, Cheng]'s Articles
[Wang, Kun]'s Articles
[Zeng, Chaoting]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: srep21013.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.