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基于数据挖掘和网络分析的“脑心同治”分子机制研究
陈迪1; 卢朋1,2; 张方博2; 唐仕欢2; 杨洪军2; 卢朋,杨洪军
Source Publication中国中药杂志
2013-01
Volume38Issue:1Pages:62-69
Abstract
研究从分子层面出发,结合利用信息技术中的网络分析、聚类和关联规则分析方法,找到步长
脑心通这一实现脑心同治的方剂中的化合物成分共同作用于人体内的主要靶标组合,并对比分析这些主要成分在基于冠心病和中风病相关的蛋白质交互作用网络中作用的节点的异同。结果从分子层面上找出该方的主要成分对于2种疾病频繁作用的共同靶标及对于2种疾病分别作用到的不同靶标,同时确了主要成分在作用于2种疾病共同靶标的同时也间接影响到不同靶标,从而解释其脑心同治的分子作用机制
; Objective:The theory of treating heart and brain simultaneously is from the theory of traditional Chinese medicine, and there aren’t enough explanations for this theory from the perspective of molecular mechanism.As one successful case of this theory, the Chinese medicine formula——BuchaIlg Naoxintong can achieve the goal of treating coronary heart disease and stroke at the same time.To illustrate the mechanism of the theory of treating heart and brain simultaneously,it is necessary to find out the molecular mechanism of this formula.Method:Using the network analysis method,together with two data mining methods-clustering and apriori algorithm,the frequent gene combinations interfered by the chemicals of the formula based on the protein—protein interaction networks relat— ed with coronary heart disease and stroke disease were figured out respectively.To find out the molecular mechanism of the theory of treating heart and brain simultaneously, the results got from two diseases were compared and analyzed Result:Based on comparing two results from these two different diseases,the mechanism of the theory of treating heart and brain simultaneously was explained from molecular level by finding out key genes targeted by the components of this formula for both diseases and some particular genes interfered by the components for each disease.In addition, genes interfered indirectly by the chemicals for different diseases were found out based on the protein-protein interaction network.Conclusion:It can help to explain the molecular mechanism of the theory by Oily methods. By finding out the molecular mechanism of this theory,it can promote the progress of combination of Chinese traditional and Western medicine.
Keyword网络分析 数据挖掘 脑心同治 步长脑心通方 分子作用机制
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11483
Collection综合信息系统研究中心
Corresponding Author卢朋,杨洪军
Affiliation1.中国科学院自动化研究所
2.中国中医科学院中药研究所
Recommended Citation
GB/T 7714
陈迪,卢朋,张方博,等. 基于数据挖掘和网络分析的“脑心同治”分子机制研究[J]. 中国中药杂志,2013,38(1):62-69.
APA 陈迪,卢朋,张方博,唐仕欢,杨洪军,&卢朋,杨洪军.(2013).基于数据挖掘和网络分析的“脑心同治”分子机制研究.中国中药杂志,38(1),62-69.
MLA 陈迪,et al."基于数据挖掘和网络分析的“脑心同治”分子机制研究".中国中药杂志 38.1(2013):62-69.
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