Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study
Wang, Jieqiong1,2; Li, Ting3; Zhou, Peng1,2; Wang, Ningli4; Xian, Junfang3; He, Huiguang1,2,5
Source PublicationBRAIN IMAGING AND BEHAVIOR
2017-08-01
Volume11Issue:4Pages:1154-1163
SubtypeArticle
AbstractTo explore the alterations of functional connectivity (FC) and connections within and between the subnetworks of the visual network and the default mode network in glaucoma. We applied the independent component analysis to obtain two resting-state networks (RSNs), which were the visual network and the default mode network (DMN), from the resting-state fMRI data of 25 primary open-angle glaucoma (POAG) patients and 25 well-matched normal controls. Then FC analysis was performed to obtain the altered FC within the RSNs, whereas the functional network connectivity (FNC) analysis was performed within and between these two RSNs. The abnormalities were correlated with clinical measures in glaucoma to investigate the abnormality-clinical relationship. FC analysis showed that the FC in the occipital pole of the visual network was decreased in POAG patients while no alterations were found in the FC of the DMN in patients. FNC analysis of connections within the RSNs found that two of the three connections within the visual network were decreased while no connection alterations were found within the DMN. FNC analysis of connections between these two RSNs found two increased connections and one decreased connection. The decreased connection between these two RSNs was positively correlated with the visual field mean deviation. These findings shed light on the importance of the reorganization of resting state networks in glaucoma mechanism, which may facilitate the understanding of glaucoma.
KeywordSubnetwork Independent Component Analysis Glaucoma Functional Connectivity Functional Network Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9597-3
WOS KeywordLATERAL GENICULATE-NUCLEUS ; AGE-RELATED-CHANGES ; BLIND SEPARATION ; OPTIC-NERVE ; BRAIN ; STIMULATION ; COMPONENTS ; SCHIZOPHRENIA ; ABNORMALITIES ; RESPONSES
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS ; 91520202 ; 81571649)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000407840500022
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20596
Collection复杂系统管理与控制国家重点实验室_影像分析与机器视觉
Affiliation1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Tongren Hosp, Dept Ophthalmol, Beijing, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jieqiong,Li, Ting,Zhou, Peng,et al. Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1154-1163.
APA Wang, Jieqiong,Li, Ting,Zhou, Peng,Wang, Ningli,Xian, Junfang,&He, Huiguang.(2017).Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study.BRAIN IMAGING AND BEHAVIOR,11(4),1154-1163.
MLA Wang, Jieqiong,et al."Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1154-1163.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Jieqiong]'s Articles
[Li, Ting]'s Articles
[Zhou, Peng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Jieqiong]'s Articles
[Li, Ting]'s Articles
[Zhou, Peng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Jieqiong]'s Articles
[Li, Ting]'s Articles
[Zhou, Peng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.