Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study
Wang, Jieqiong1,2; Li, Ting3; Zhou, Peng1,2; Wang, Ningli4; Xian, Junfang3; He, Huiguang1,2,5
2017-08-01
发表期刊BRAIN IMAGING AND BEHAVIOR
卷号11期号:4页码:1154-1163
文章类型Article
摘要To explore the alterations of functional connectivity (FC) and connections within and between the subnetworks of the visual network and the default mode network in glaucoma. We applied the independent component analysis to obtain two resting-state networks (RSNs), which were the visual network and the default mode network (DMN), from the resting-state fMRI data of 25 primary open-angle glaucoma (POAG) patients and 25 well-matched normal controls. Then FC analysis was performed to obtain the altered FC within the RSNs, whereas the functional network connectivity (FNC) analysis was performed within and between these two RSNs. The abnormalities were correlated with clinical measures in glaucoma to investigate the abnormality-clinical relationship. FC analysis showed that the FC in the occipital pole of the visual network was decreased in POAG patients while no alterations were found in the FC of the DMN in patients. FNC analysis of connections within the RSNs found that two of the three connections within the visual network were decreased while no connection alterations were found within the DMN. FNC analysis of connections between these two RSNs found two increased connections and one decreased connection. The decreased connection between these two RSNs was positively correlated with the visual field mean deviation. These findings shed light on the importance of the reorganization of resting state networks in glaucoma mechanism, which may facilitate the understanding of glaucoma.
关键词Subnetwork Independent Component Analysis Glaucoma Functional Connectivity Functional Network Connectivity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9597-3
关键词[WOS]LATERAL GENICULATE-NUCLEUS ; AGE-RELATED-CHANGES ; BLIND SEPARATION ; OPTIC-NERVE ; BRAIN ; STIMULATION ; COMPONENTS ; SCHIZOPHRENIA ; ABNORMALITIES ; RESPONSES
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS ; 91520202 ; 81571649)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000407840500022
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20596
专题复杂系统管理与控制国家重点实验室_影像分析与机器视觉
作者单位1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Tongren Hosp, Dept Ophthalmol, Beijing, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
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Wang, Jieqiong,Li, Ting,Zhou, Peng,et al. Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1154-1163.
APA Wang, Jieqiong,Li, Ting,Zhou, Peng,Wang, Ningli,Xian, Junfang,&He, Huiguang.(2017).Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study.BRAIN IMAGING AND BEHAVIOR,11(4),1154-1163.
MLA Wang, Jieqiong,et al."Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1154-1163.
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