| Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders | |
Xiao, Xiao1; Wang, Lu1; Wang, Chuang2; Yuan, Ti-Fei3; Zhou, Dongsheng4; Zheng, Fanfan5 ; Li, Lingyi1; Grigoroiu-Serbanescu, Maria6; Ikeda, Masashi7; Iwata, Nakao7; Takahashi, Atsushi8,9; Kamatani, Yoichiro8; Kubo, Michiaki10; Preisig, Martin11; Kutalik, Zoltan12,13; Castelao, Enrique11; Pistis, Giorgio11; Amin, Najaf14; van Duijn, Cornelia M.14; Forstner, Andreas J.15,16,17,18,19; Strohmaier, Jana20; Hecker, Julian15,21; Schulze, Thomas G.22; Mueller-Myhsok, Bertram23,24,25; Reif, Andreas26; Mitchell, Philip B.27,28; Martin, Nicholas G.29; Schofield, Peter R.30,31; Cichon, Sven15,16,17,19,32; Noethen, Markus M.15,16; Chang, Hong1; Luo, Xiong-Jian1; Fang, Yiru33; Yao, Yong-Gang1,34; Zhang, Chen33; Rietschel, Marcella; Li, Ming1,34; Adv Collaborative Study Mood Dis; MooDS Bipolar Consortium
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| 发表期刊 | TRANSLATIONAL PSYCHIATRY
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| 2017-12-11 | |
| 卷号 | 7 |
| 文章类型 | Article |
| 摘要 | Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer the opportunity to examine this topic by utilizing large amounts of combined genetic data, which should ultimately allow a better understanding of the onset and development of these illnesses. Genome-wide meta-analysis was performed by combining two GWAS data sets on BPD and MDD (19,637 cases and 18,083 controls), followed by replication analyses for the loci of interest in independent 12,364 cases and 76,633 controls from additional samples that were not included in the two GWAS data sets. The single-nucleotide polymorphism (SNP) rs10791889 at 11q13.2 was significant in both discovery and replication samples. When combining all samples, this SNP and multiple other SNPs at 2q11.2 (rs717454), 8q21.3 (rs10103191), and 11q13.2 (rs2167457) exhibited genome-wide significant association with major mood disorders. The SNPs in 2q11.2 and 8q21.3 were novel risk SNPs that were not previously reported, and SNPs at 11q13.2 were in high LD with potential BPD risk SNPs implicated in a previous GWAS. The genome-wide significant loci at 2q11.2 and 11q13.2 exhibited strong effects on the mRNA expression of certain nearby genes in cerebellum. In conclusion, we have identified several novel loci associated with major mood disorders, adding further support for shared genetic risk between BPD and MDD. Our study highlights the necessity and importance of mining public data sets to explore risk genes for complex diseases such as mood disorders. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1038/s41398-017-0019-0 |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; BIPOLAR DISORDER ; DEPRESSIVE DISORDER ; GENE-EXPRESSION ; HIPPOCAMPAL STRUCTURE ; EUROPEAN POPULATIONS ; ALLELIC DIFFERENCES ; CONFERS RISK ; HAN CHINESE ; SUSCEPTIBILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13000000) ; CAS Pioneer Hundred Talents Program ; German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the the e:Med Programme(01ZX1314A ; German Research Foundation (DFG)(FOR2107 ; UEFISCDI, Bucharest, Romania(89/2012) ; German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent(01ZX1314A) ; Australian National Health ; Medical Research Council(GNT1037196) ; European Commission FP6 STRP grant(018947 (LSHG-CT-2006-01947)) ; European Community's Seventh Framework Programme (FP7) by the European Commission under the programme "Quality of Life and Management of the Living Resources" of 5th Framework Programme(HEALTH-F4-2007-201413 ; Netherlands Organization for Scientific Research ; Russian Foundation for Basic Research(NWO-RFBR 047.017.043) ; ZonMw grant(91111025) ; Hersenstichting Nederland(F2013(1)-28) ; 01ZX1314G) ; 11-1 ; QLG2-CT-2002-01254) ; NO246/10-1) |
| WOS研究方向 | Psychiatry |
| WOS类目 | Psychiatry |
| WOS记录号 | WOS:000419040900001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/20757 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China 2.Ningbo Univ, Sch Med, Prov Key Lab Pathophysiol, Dept Pharmacol, Ningbo, Zhejiang, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China 4.Ningbo Kangning Hosp, Ningbo, Zhejiang, Peoples R China 5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 6.Alexandru Obregia Clin Psychiat Hosp, Biometr Psychiat Genet Res Unit, Bucharest, Romania 7.Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan 8.RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan 9.Natl Cerebral & Cardiovasc Ctr, Omics Res Ctr, Lab Omics Informat, Osaka, Japan 10.RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan 11.CHU Vaudois, Dept Psychiat, Prilly, Switzerland 12.CHU Vaudois, Inst Social & Prevent Med, Lausanne, Switzerland 13.Swiss Inst Bioinformat, Lausanne, Switzerland 14.Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands 15.Univ Bonn, Inst Human Genet, Bonn, Germany 16.Univ Bonn, Life & Brain Ctr, Dept Gen, Bonn, Germany 17.Univ Basel, Dept Biomed, Human Genom Res Grp, Basel, Switzerland 18.Univ Basel, Dept Psychiat UPK, Basel, Switzerland 19.Univ Basel Hosp, Inst Med Genet & Pathol, Basel, Switzerland 20.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol, Mannheim, Germany 21.Univ Bonn, Inst Genom Math, Bonn, Germany 22.Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Gen, Munich, Germany 23.Max Planck Inst Psychiat, Munich, Germany 24.Munich Cluster Syst Neurol SyNergy, Munich, Germany 25.Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England 26.Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany 27.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia 28.Black Dog Inst, Sydney, NSW, Australia 29.QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia 30.Neurosci Res Australia, Sydney, NSW, Australia 31.Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia 32.Res Ctr Julich, Struct & Funct Org Brain Genom Imaging, Inst Neurosci & Med INM 1, Julich, Germany 33.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai, Peoples R China 34.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Xiao,Wang, Lu,Wang, Chuang,et al. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders[J]. TRANSLATIONAL PSYCHIATRY,2017,7. |
| APA | Xiao, Xiao.,Wang, Lu.,Wang, Chuang.,Yuan, Ti-Fei.,Zhou, Dongsheng.,...&MooDS Bipolar Consortium.(2017).Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.TRANSLATIONAL PSYCHIATRY,7. |
| MLA | Xiao, Xiao,et al."Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders".TRANSLATIONAL PSYCHIATRY 7(2017). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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