Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study

doi:10.1136/gutjnl-2018-316204

	Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study
	Wang, Kun1,2 ; Lu, Xue 1; Zhou, Hui2,3 ; Gao, Yongyan 4; Zheng, Jian 1,5; Tong, Minghui 6; Wu, Changjun 7; Liu, Changzhu 8; Huang, Liping 9; Jiang, Tian'an 10; Meng, Fankun 11; Lu, Yongping 12; Ai, Hong 13; Xie, Xiao-Yan 14; Yin, Li-Ping 15; Liang, Ping 3; Tian, Jie 2,3; Zheng, Rongqin 1
发表期刊	GUT
ISSN	0017-5749
	2019-04-01
卷号	68 期号:4 页码:729-741
通讯作者	Liang, Ping(liangping301@hotmail.com) ; Tian, Jie(jie.tian@ia.ac.cn) ; Zheng, Rongqin(zhengrq@mail.sysu.edu.cn)
摘要	Objective We aimed to evaluate the performance of the newly developed deep learning Radiomics of elastography (DLRE) for assessing liver fibrosis stages. DLRE adopts the radiomic strategy for quantitative analysis of the heterogeneity in two-dimensional shear wave elastography (2D-SWE) images. Design A prospective multicentre study was conducted to assess its accuracy in patients with chronic hepatitis B, in comparison with 2D-SWE, aspartate transaminase-to-platelet ratio index and fibrosis index based on four factors, by using liver biopsy as the reference standard. Its accuracy and robustness were also investigated by applying different number of acquisitions and different training cohorts, respectively. Data of 654 potentially eligible patients were prospectively enrolled from 12 hospitals, and finally 398 patients with 1990 images were included. Analysis of receiver operating characteristic (ROC) curves was performed to calculate the optimal area under the ROC curve (AUC) for cirrhosis (F4), advanced fibrosis (>= F3) and significance fibrosis (>= F2). Results AUCs of DLRE were 0.97 for F4 (95% CI 0.94 to 0.99), 0.98 for >= F3 (95% CI 0.96 to 1.00) and 0.85 (95% CI 0.81 to 0.89) for >= F2, which were significantly better than other methods except 2D-SWE in >= F2. Its diagnostic accuracy improved as more images (especially >= 3 images) were acquired from each individual. No significant variation of the performance was found if different training cohorts were applied. Conclusion DLRE shows the best overall performance in predicting liver fibrosis stages compared with 2D-SWE and biomarkers. It is valuable and practical for the non-invasive accurate diagnosis of liver fibrosis stages in HBV-infected patients.
DOI	10.1136/gutjnl-2018-316204
关键词[WOS]	CONVOLUTIONAL NEURAL-NETWORKS ; SIMPLE NONINVASIVE INDEX ; ACCURACY ; STIFFNESS ; CLASSIFICATION ; ALGORITHM ; PREDICT ; UPDATE
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61401462] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61401462] ; Beijing Municipal Science and Technology Commission[Z161100002616022]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission
WOS研究方向	Gastroenterology & Hepatology
WOS类目	Gastroenterology & Hepatology
WOS记录号	WOS:000471830300018
出版者	BMJ PUBLISHING GROUP
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：269[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/25829
专题	中国科学院分子影像重点实验室
通讯作者	Liang, Ping; Tian, Jie; Zheng, Rongqin
作者单位	1.Sun Yat Sen Univ, Dept Med Ultrasound, Guangdong Key Lab Liver Dis Res, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Dept Artificial Intelligence Technol, Beijing, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China 5.Third Hosp Longgang, Dept Med Ultrason, Shenzhen, Peoples R China 6.Lanzhou Univ, Funct Examinat Dept, Hosp 2, Childrens Hosp, Lanzhou, Gansu, Peoples R China 7.Harbin Med Univ, Dept Ultrasound, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China 8.Guangzhou Eighth Peoples Hosp, Ultrasound Dept, Guangzhou, Guangdong, Peoples R China 9.China Med Univ, Dept Ultrasound, Shengjing Hosp, Shenyang, Liaoning, Peoples R China 10.Zhejiang Univ, Affiliated Hosp 1, Dept Ultrasonog, Med Coll, Hangzhou, Zhejiang, Peoples R China 11.Capital Med Univ, Beijing Youan Hosp, Funct Diag Ctr, Beijing, Peoples R China 12.Second Peoples Hosp Yunnan Prov, Ultrasound Dept, Kunming, Yunnan, Peoples R China 13.Xi An Jiao Tong Univ, Ultrasound Dept, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China 14.Sun Yat sen Univ, Inst Diagnost & Intervent Ultrasound, Dept Med Ultrason, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 15.Nanjing Univ TCM, Jiangsu Prov Hosp TCM, Dept Ultrasound, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China
第一作者单位	中国科学院分子影像重点实验室
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Wang, Kun,Lu, Xue,Zhou, Hui,et al. Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study[J]. GUT,2019,68(4):729-741.
APA	Wang, Kun.,Lu, Xue.,Zhou, Hui.,Gao, Yongyan.,Zheng, Jian.,...&Zheng, Rongqin.(2019).Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study.GUT,68(4),729-741.
MLA	Wang, Kun,et al."Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study".GUT 68.4(2019):729-741.

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