Residual cancerous lesion and vein tumour thrombus identified intraoperatively using a fluorescence navigation system in liver surgery

doi:10.1111/ans.15282

	Residual cancerous lesion and vein tumour thrombus identified intraoperatively using a fluorescence navigation system in liver surgery
	He, Pan 1,2; Su, Song 1; Fang, Cheng 1; He, Kai 1; Chi, Chongwei3,4 ; Xia, Xianming 1; Tian, Jie 3; Li, Bo 1
发表期刊	ANZ JOURNAL OF SURGERY
ISSN	1445-1433
	2019-07-01
卷号	89 期号:7-8 页码:E308-E314
通讯作者	Li, Bo(liboer2002@126.com)
摘要	Aim The main aims of this study are to investigate the clinical application value of using indocyanine green fluorescence imaging for ensuring complete resection of tumour tissue during hepatectomy and to evaluate the diagnostic efficacy of near-infrared (NIR) fluorescence imaging system using indocyanine green in hepatectomy. Methods After undergoing liver resection at the Affiliated Hospital of Southwest Medical University from July 2017 to May 2018, 35 eligible patients were included in this study. The liver surface and resection margin were intraoperatively assessed by intraoperative ultrasonography and NIR fluorescence imaging, after intravenous administration of indocyanine green (0.5 mg/kg) 72-96 h prior to surgery. The intraoperative observations were compared with the pathological findings in the liver. Results In the 35 patients, a total of 53 lesions were found, of which 42 were malignant lesions. The analysis results showed that the sensitivity and accuracy of detection using NIR fluorescence imaging were significantly higher than with intraoperative ultrasonography (P < 0.05). However, there was no difference between contrast-enhanced helical computed tomography and NIR fluorescence imaging in finding lesions (P > 0.05). In addition, 11 new suspicious lesions were detected only by NIR fluorescence imaging in the liver surface and resection margin during surgery, four of which were hepatocellular carcinoma. We also detected four vein tumour thrombi using the NIR fluorescence navigation system. Conclusions The NIR fluorescence navigation system enables the identification of small tumours, residual cancer tissues in resection margin and venous tumour embolies in real time and enhances the accuracy and integrity of liver resection.
关键词	hepatectomy hepatocellular carcinoma liver near infrared
DOI	10.1111/ans.15282
关键词[WOS]	EARLY HEPATOCELLULAR-CARCINOMA ; INDOCYANINE GREEN ; GUIDED SURGERY ; RESECTION ; TRANSPLANTATION
收录类别	SCI
语种	英语
WOS研究方向	Surgery
WOS类目	Surgery
WOS记录号	WOS:000478741700005
出版者	WILEY
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/27521
专题	中国科学院分子影像重点实验室
通讯作者	Li, Bo
作者单位	1.Southwest Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Luzhou 646000, Peoples R China 2.Southwest Med Univ, Affiliated Hosp, Dept Anesthesiol, Luzhou, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China 4.Beijing Digital Precis Med Technol Co Ltd, Beijing, Peoples R China
推荐引用方式 GB/T 7714	He, Pan,Su, Song,Fang, Cheng,et al. Residual cancerous lesion and vein tumour thrombus identified intraoperatively using a fluorescence navigation system in liver surgery[J]. ANZ JOURNAL OF SURGERY,2019,89(7-8):E308-E314.
APA	He, Pan.,Su, Song.,Fang, Cheng.,He, Kai.,Chi, Chongwei.,...&Li, Bo.(2019).Residual cancerous lesion and vein tumour thrombus identified intraoperatively using a fluorescence navigation system in liver surgery.ANZ JOURNAL OF SURGERY,89(7-8),E308-E314.
MLA	He, Pan,et al."Residual cancerous lesion and vein tumour thrombus identified intraoperatively using a fluorescence navigation system in liver surgery".ANZ JOURNAL OF SURGERY 89.7-8(2019):E308-E314.