CASIA OpenIR
A neural circuit for comorbid depressive symptoms in chronic pain
Zhou, Wenjie1; Jin, Yan1; Meng, Qian1; Zhu, Xia1; Bai, Tongjian2,3; Tian, Yanghua2,3; Mao, Yu1,2,3; Wang, Likui2,3; Xie, Wen4; Zhong, Hui4; Zhang, Na5,6; Luo, Min-Hua7; Tao, Wenjuan1; Wang, Haitao1; Li, Jie1; Li, Juan1; Qiu, Ben-Sheng1; Zhou, Jiang-Ning1; Li, Xiangyao8; Xu, Han8; Wang, Kai2,3; Zhang, Xiaochu1; Liu, Yong9; Richter-Levin, Gal10; Xu, Lin5,6; Zhang, Zhi1
Source PublicationNATURE NEUROSCIENCE
ISSN1097-6256
2019-10-01
Volume22Issue:10Pages:1649-+
Corresponding AuthorZhang, Zhi(zhizhang@ustc.edu.cn)
AbstractComorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). The SOMCeA neurons project directly to the lateral habenula, an area known involved in depression. Inhibition of the 5-HTDRN -> SOMCeA pathway produced depression-like behavior in a male mouse model of chronic pain. Activation of this pathway using pharmacological or optogenetic approaches reduced depression-like behavior in these mice. Human functional magnetic resonance imaging data showed that compared to healthy controls, functional connectivity between the CeA-containing centromedial amygdala and the DRN was reduced in patients with CDS but not in patients in chronic pain without depression. These findings indicate that a novel 5-HTDRN -> SOMCeA -> lateral habenula pathway may mediate at least some aspects of CDS.
DOI10.1038/s41593-019-0468-2
WOS KeywordPREFRONTAL CORTEX ; IN-VIVO ; AMYGDALA ; HABENULA ; MECHANISMS ; EXPERIENCE ; DISORDER ; NEURONS ; ANXIETY ; STRESS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31600851] ; National Natural Science Foundation of China[81600964] ; National Natural Science Foundation of China[81870877] ; National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[91849119] ; National Key Research and Development Program of China[2016YFC1305900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02010000] ; National Natural Science Foundation of China[31600851] ; National Natural Science Foundation of China[81600964] ; National Natural Science Foundation of China[81870877] ; National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[91849119] ; National Key Research and Development Program of China[2016YFC1305900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02010000]
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000493396200015
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/28905
Collection中国科学院自动化研究所
Corresponding AuthorZhang, Zhi
Affiliation1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Brain Funct & Dis, Hefei, Anhui, Peoples R China
2.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Dept Anesthesiol, Hefei, Anhui, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Dept Pain Management, Hefei, Anhui, Peoples R China
4.Anhui Mental Hlth Ctr, Dept Psychol, Hefei, Anhui, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China
6.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming, Yunnan, Peoples R China
7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China
8.Zhejiang Univ, Key Lab Neurobiol Zhejiang Prov, Dept Neurobiol,Sch Med, Key Lab Med Neurobiol,Minist Hlth China, Hangzhou, Zhejiang, Peoples R China
9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
10.Univ Haifa, Sagol Dept Neurobiol, Haifa, Israel
Recommended Citation
GB/T 7714
Zhou, Wenjie,Jin, Yan,Meng, Qian,et al. A neural circuit for comorbid depressive symptoms in chronic pain[J]. NATURE NEUROSCIENCE,2019,22(10):1649-+.
APA Zhou, Wenjie.,Jin, Yan.,Meng, Qian.,Zhu, Xia.,Bai, Tongjian.,...&Zhang, Zhi.(2019).A neural circuit for comorbid depressive symptoms in chronic pain.NATURE NEUROSCIENCE,22(10),1649-+.
MLA Zhou, Wenjie,et al."A neural circuit for comorbid depressive symptoms in chronic pain".NATURE NEUROSCIENCE 22.10(2019):1649-+.
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