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Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity
Liu, Shu1,2,3; Li, Ang1,2,3; Liu, Yong1,2,3; Yan, Hao4,5; Wang, Meng1,2,3; Sun, Yuqing1,2,3; Fan, Lingzhong1,2,3; Song, Ming1,2,3; Xu, Kaibin1,2,3; Chen, Jun6; Chen, Yunchun7; Wang, Huaning7; Guo, Hua8; Wan, Ping8; Lv, Luxian9,10; Yang, Yongfeng9,10; Li, Peng4,5; Lu, Lin4,5; Yan, Jun4,5; Wang, Huiling6; Zhang, Hongxing9,10; Wu, Huawang11; Ning, Yuping11; Zhang, Dai4,5; Jiang, Tianzi1,2,3; Liu, Bing1,2,3
发表期刊BRITISH JOURNAL OF PSYCHIATRY
ISSN0007-1250
2020-05-01
卷号216期号:5页码:267-274
摘要

Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated. Aims To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia. Method Genomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant. Results The imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia. Conclusions These findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia.

关键词Schizophrenia polygenic risk score hippocampus grey matter volume functional connectivity
DOI10.1192/bjp.2019.127
关键词[WOS]RISK ; MEMORY ; ASSOCIATION ; LOCI
收录类别SCI
语种英语
资助项目National Key Research and Development Plan[2016YFC0904300] ; Strategic Priority Research Program of Chinese Academy of Science[XDBS01020200] ; Natural Science Foundation of China[31300934] ; Natural Science Foundation of China[81771451]
项目资助者National Key Research and Development Plan ; Strategic Priority Research Program of Chinese Academy of Science ; Natural Science Foundation of China
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000528889400007
出版者CAMBRIDGE UNIV PRESS
七大方向——子方向分类脑网络分析
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/39404
专题脑网络组研究
通讯作者Liu, Bing
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
4.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China
5.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
6.Wuhan Univ, Renmin Hosp, Dept Radiol, Wuhan, Peoples R China
7.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China
8.Zhumadian Psychiat Hosp, Zhumadian, Peoples R China
9.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Henan, Peoples R China
10.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China
11.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Brain Hosp, Guangzhou, Peoples R China
第一作者单位中国科学院自动化研究所;  模式识别国家重点实验室
通讯作者单位中国科学院自动化研究所;  模式识别国家重点实验室
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GB/T 7714
Liu, Shu,Li, Ang,Liu, Yong,et al. Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity[J]. BRITISH JOURNAL OF PSYCHIATRY,2020,216(5):267-274.
APA Liu, Shu.,Li, Ang.,Liu, Yong.,Yan, Hao.,Wang, Meng.,...&Liu, Bing.(2020).Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity.BRITISH JOURNAL OF PSYCHIATRY,216(5),267-274.
MLA Liu, Shu,et al."Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity".BRITISH JOURNAL OF PSYCHIATRY 216.5(2020):267-274.
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