Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity | |
Liu, Shu1,2,3; Li, Ang1,2,3; Liu, Yong1,2,3; Yan, Hao4,5; Wang, Meng1,2,3; Sun, Yuqing1,2,3; Fan, Lingzhong1,2,3; Song, Ming1,2,3; Xu, Kaibin1,2,3; Chen, Jun6; Chen, Yunchun7; Wang, Huaning7; Guo, Hua8; Wan, Ping8; Lv, Luxian9,10; Yang, Yongfeng9,10; Li, Peng4,5; Lu, Lin4,5; Yan, Jun4,5; Wang, Huiling6; Zhang, Hongxing9,10; Wu, Huawang11; Ning, Yuping11; Zhang, Dai4,5; Jiang, Tianzi1,2,3; Liu, Bing1,2,3 | |
发表期刊 | BRITISH JOURNAL OF PSYCHIATRY |
ISSN | 0007-1250 |
2020-05-01 | |
卷号 | 216期号:5页码:267-274 |
摘要 | Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated. Aims To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia. Method Genomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant. Results The imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia. Conclusions These findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia. |
关键词 | Schizophrenia polygenic risk score hippocampus grey matter volume functional connectivity |
DOI | 10.1192/bjp.2019.127 |
关键词[WOS] | RISK ; MEMORY ; ASSOCIATION ; LOCI |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key Research and Development Plan[2016YFC0904300] ; Strategic Priority Research Program of Chinese Academy of Science[XDBS01020200] ; Natural Science Foundation of China[31300934] ; Natural Science Foundation of China[81771451] |
项目资助者 | National Key Research and Development Plan ; Strategic Priority Research Program of Chinese Academy of Science ; Natural Science Foundation of China |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000528889400007 |
出版者 | CAMBRIDGE UNIV PRESS |
七大方向——子方向分类 | 脑网络分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/39404 |
专题 | 脑网络组研究 |
通讯作者 | Liu, Bing |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 4.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China 5.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China 6.Wuhan Univ, Renmin Hosp, Dept Radiol, Wuhan, Peoples R China 7.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China 8.Zhumadian Psychiat Hosp, Zhumadian, Peoples R China 9.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Henan, Peoples R China 10.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China 11.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Brain Hosp, Guangzhou, Peoples R China |
第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
通讯作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Shu,Li, Ang,Liu, Yong,et al. Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity[J]. BRITISH JOURNAL OF PSYCHIATRY,2020,216(5):267-274. |
APA | Liu, Shu.,Li, Ang.,Liu, Yong.,Yan, Hao.,Wang, Meng.,...&Liu, Bing.(2020).Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity.BRITISH JOURNAL OF PSYCHIATRY,216(5),267-274. |
MLA | Liu, Shu,et al."Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity".BRITISH JOURNAL OF PSYCHIATRY 216.5(2020):267-274. |
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