Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study

doi:10.1016/j.jbspin.2020.09.010

CASIA OpenIR > 多模态人工智能系统全国重点实验室 > 平行智能技术与系统团队

	Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study
	Gao, Qianhui 1,2; Cheng, Xiaoyu 1,2; Merriman, Tony R.3,4,5; Wang, Can1,2 ; Cui, Lingling 1,2; Zhang, Hui3 ; Sun, Wenyan 3; Wang, Jing 6,7; Wang, Feiyue6,7 ; Li, Changgui 1,2,3; Lu, Jie 1,2,3
发表期刊	JOINT BONE SPINE
ISSN	1297-319X
	2021-12-01
卷号	88 期号:6 页码:6
通讯作者	Lu, Jie(13127006046@163.com)
摘要	Objective: The prevalence of gout is increasing but studies of its clinical features in large samples are lacking. This study aimed to clarify changes in the clinical manifestations of gout in China over the last decade and investigate the clinical features and risk factors of early-onset gout. Methods: Clinical manifestations were compared between 9754 gout patients who first presented at our clinic with gout in 2008-2012 (earlier group) or 2013-2018 (later group). Gout onset <= 30 years old was defined as early-onset and > 30 years as late-onset. Clinical features and risk factors were compared between the groups. Results: The gout-onset age was 4.14 years younger and the percentage of early-onset gout (3827 patients) was higher in the later 2013-2018 group (5979 patients). The disease duration was significantly shorter (5.72 +/- 0.09 vs. 6.01 +/- 0.11 years P < 0,05) and the ratio of patients with tophi was correspondingly lower in the later group (22.0% vs. 20.0%, P < 0,05). More patients were obese (32.6% vs. 37.7%, P < 0.001) and serum urate levels (465.0 +/- 1.9 mu mol/L vs. 485.5 +/- 1.5 mu mol/L) were significantly higher in the later group. As the age of gout-onset became younger, we did the multivariate logistic regression and identified a positive family history, male sex, obesity, elevated serum urate, and sugar-sweetened soft drinks as independent predictors of early-onset gout. Conclusion: The manifestations of gout in China have changed over the last decade, associated with trend towards younger onset. (C) 2020 Socie acute accent te acute accent franc , aise de rhumatologie. Published by Elsevier Masson SAS.
关键词	Gout Early-onset Risk factors
DOI	10.1016/j.jbspin.2020.09.010
关键词[WOS]	URIC-ACID ; YOUNGER AGE ; HYPERURICEMIA ; OBESITY ; ONSET ; RISK ; PREVALENCE
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program[2016YFC0903400] ; National Natural Science Foundation of China[31900413] ; National Natural Science Foundation of China[81520108007] ; National Natural Science Foundation of China[81770869]
项目资助者	National Key Research and Development Program ; National Natural Science Foundation of China
WOS研究方向	Rheumatology
WOS类目	Rheumatology
WOS记录号	WOS:000722025600001
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/46543
专题	多模态人工智能系统全国重点实验室_平行智能技术与系统团队
通讯作者	Lu, Jie
作者单位	1.Qingdao Univ, Affiliated Hosp, Dept Endocrinol & Metab, Shandong Prov Key Lab Metab Dis, Qingdao 266003, Peoples R China 2.Qingdao Univ, Affiliated Hosp, Dept Endocrinol & Metab, Qingdao Key Lab Gout, Qingdao 266003, Peoples R China 3.Qingdao Univ, Inst Metab Dis, Qingdao 266003, Peoples R China 4.Univ Otago, Dept Biochem, Dunedin, New Zealand 5.Univ Alabama Birmingham, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA 6.Qingdao Acad Intelligent Ind, Inst Smart Healthcare Syst, Qingdao 266109, Peoples R China 7.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Gao, Qianhui,Cheng, Xiaoyu,Merriman, Tony R.,et al. Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study[J]. JOINT BONE SPINE,2021,88(6):6.
APA	Gao, Qianhui.,Cheng, Xiaoyu.,Merriman, Tony R..,Wang, Can.,Cui, Lingling.,...&Lu, Jie.(2021).Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study.JOINT BONE SPINE,88(6),6.
MLA	Gao, Qianhui,et al."Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study".JOINT BONE SPINE 88.6(2021):6.