Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients

doi:10.1016/j.brs.2021.12.008

	Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients
	Xin, Yumeng 1,5,6; Bai, Tongjian 7,8,9; Zhang, Ting10 ; Chen, Yang 11; Wang, Kai 7,8,9,12,13; Yu, Shan3,4,5,14 ; Liu, Ning 1,5,12; Tian, Yanghua 2,12
发表期刊	BRAIN STIMULATION
ISSN	1935-861X
	2022
卷号	15 期号:1 页码:214-225
通讯作者	Yu, Shan(shan.yu@nlpr.ia.ac.cn) ; Liu, Ning(liuning@ibp.ac.cn) ; Tian, Yanghua(ayfytyh@126.com)
摘要	Background: Electroconvulsive therapy (ECT) is widely considered as an effective and fast-acting option for treating patients with major depressive disorder (MDD). However, the neural basis underlying this powerful therapy remains uncertain. Recent studies have suggested that the healthy brain may operate near a critical state, which may reflect a balance between neuronal excitation and inhibition. Objective: In the present study, we investigated whether there are any changes regarding criticality in MDD and, if so, whether ECT can reverse them. Critical dynamics analyses were performed on restingstate functional magnetic resonance imaging (rs-fMRI) data collected from 39 MDD patients and 38 healthy controls (HCs). Results: We found that compared with HCs, MDD patients, especially those who responded positively to ECT, tended to have smaller average avalanch sizes and lower branching ratios, suggesting a sub-critical state, at both the whole-brain and functional network levels. Importantly, ECT effectively corrected such anomalies, accompanied by enhanced degree centrality and functional connectivity of high-degree nodes located in the networks including the default-mode and the frontoparietal networks. Conclusion: These results indicate that ECT can modulate large-scale brain dynamics of MDD patients to be closer to criticality. Our study sheds new light on the pathology of MDD and the network mechanism by which ECT influences treatment. (C) 2021 The Authors. Published by Elsevier Inc.
关键词	Major depressive disorder Electroconvulsive therapy Criticality Neuronal avalanches
DOI	10.1016/j.brs.2021.12.008
关键词[WOS]	NEURONAL AVALANCHES ; CORTICAL NETWORKS ; FUNCTIONAL CONNECTIVITY ; OSCILLATIONS ; ORGANIZATION ; METAANALYSIS ; PREDICTION ; REMISSION ; ECT ; MEG
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0105203] ; Beijing Advanced Discipline Fund ; Strategic Priority Research Program of Chinese Academy of Science[XDB32020207] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32040200] ; Chinese Academy of Sciences[QYZDB-SSW-SMC033] ; National Natural Science Foundation of China[32071054] ; National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[31970979] ; National Natural Science Foundation of China[82090034] ; Science Fund for Distinguished Young Scholars of Anhui Province[1808085J23] ; Beijing Academy of Artificial Intelligence
项目资助者	National Key Research and Development Program of China ; Beijing Advanced Discipline Fund ; Strategic Priority Research Program of Chinese Academy of Science ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; Science Fund for Distinguished Young Scholars of Anhui Province ; Beijing Academy of Artificial Intelligence
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:000800708100009
出版者	ELSEVIER SCIENCE INC
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/49492
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Yu, Shan; Liu, Ning; Tian, Yanghua
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, 15 Datun Rd, Beijing 100101, Peoples R China 2.Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei 230601, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 6.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 7.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China 8.Anhui Prov Key Lab Cognit & Neuropsychiat Disorde, Hefei 230032, Peoples R China 9.Collaborat Innovat Ctr Neuropsychiat Disorders &, Hefei 230032, Peoples R China 10.Anhui Med Univ, Dept Psychiat, Affiliated Hosp 2, Hefei 230601, Peoples R China 11.Anhui Mental Hlth Ctr, Hefei 230022, Peoples R China 12.Hefei Comprehens Natl Sci Ctr, Inst Artificial Intelligence, Hefei 230031, Peoples R China 13.Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Hefei 230032, Peoples R China 14.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Xin, Yumeng,Bai, Tongjian,Zhang, Ting,et al. Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients[J]. BRAIN STIMULATION,2022,15(1):214-225.
APA	Xin, Yumeng.,Bai, Tongjian.,Zhang, Ting.,Chen, Yang.,Wang, Kai.,...&Tian, Yanghua.(2022).Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients.BRAIN STIMULATION,15(1),214-225.
MLA	Xin, Yumeng,et al."Electroconvulsive therapy modulates critical brain dynamics in major depressive disorder patients".BRAIN STIMULATION 15.1(2022):214-225.