Knowledge Commons of Institute of Automation,CAS
The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods | |
Zhao, Yuxin1,2; Wang, Meng1,2; Hu, Ke1,2; Wang, Qi1,2; Lou, Jing3; Fan, Lingzhong1,2,4; Liu, Bing3,5 | |
发表期刊 | CEREBRAL CORTEX |
ISSN | 1047-3211 |
2022-09-07 | |
页码 | 14 |
摘要 | The human cerebral cortex conforms to specific functional hierarchies facilitating information processing and higher-order cognition. Prior studies in adults have unveiled a dominant functional hierarchy spanning from sensorimotor regions to transmodal regions, which is also present in younger cohorts. However, how the functional hierarchy develops and the underlying molecular mechanisms remain to be investigated. Here, we set out to investigate the developmental patterns of the functional hierarchy for preschool children (#scans = 141, age = 2.41-6.90 years) using a parsimonious general linear model and the underlying biological mechanisms by combining the neuroimaging developmental pattern with two separate transcriptomic datasets (i.e. Allen Human Brain Atlas and BrainSpan Atlas). Our results indicated that transmodal regions were further segregated from sensorimotor regions and that such changes were potentially driven by two gene clusters with distinct enrichment profiles, namely prenatal gene cluster and postnatal gene cluster. Additionally, we found similar developmental profiles manifested in subsequent developmental periods by conducting identical analyses on the Human Connectome Projects in Development (#scans = 638, age = 5.58-21.92 years) and Philadelphia Neurodevelopment Cohort datasets (#scans = 795, age = 8-21 years), driven by concordant two gene clusters. Together, these findings illuminate a comprehensive developmental principle of the functional hierarchy and the underpinning molecular factors, and thus may shed light on the potential pathobiology of neurodevelopmental disorders. |
关键词 | cortical development fMRI gene expression postnatal prenatal |
DOI | 10.1093/cercor/bhac340 |
关键词[WOS] | DEFAULT-MODE NETWORK ; GENETIC-CONTROL ; CONNECTIVITY ; CONNECTOME ; EXPRESSION ; DYNAMICS ; PATTERNS ; DISRUPTION ; EMERGENCE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foun-dation of China[81771451] ; Startup Funds of Beijing Normal University |
项目资助者 | National Natural Science Foun-dation of China ; Startup Funds of Beijing Normal University |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000850608200001 |
出版者 | OXFORD UNIV PRESS INC |
是否为代表性论文 | 是 |
七大方向——子方向分类 | 脑网络分析 |
国重实验室规划方向分类 | 认知机理与类脑学习 |
是否有论文关联数据集需要存交 | 否 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/50039 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Liu, Bing |
作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr & Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 5.Chinese Inst Brain Res, Beijing 102206, Peoples R China |
第一作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhao, Yuxin,Wang, Meng,Hu, Ke,et al. The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods[J]. CEREBRAL CORTEX,2022:14. |
APA | Zhao, Yuxin.,Wang, Meng.,Hu, Ke.,Wang, Qi.,Lou, Jing.,...&Liu, Bing.(2022).The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods.CEREBRAL CORTEX,14. |
MLA | Zhao, Yuxin,et al."The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods".CEREBRAL CORTEX (2022):14. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
bhac340.pdf(1943KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论