NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient

doi:10.1016/j.pdpdt.2022.103098

	NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient
	Zhang, Zeyu1,2 ; Fang, Cheng 3; Zhang, Yang4 ; Su, Song 3; Li, Bo 3; Liu, Gang 4; Hu, Zhenhua2,5 ; Tian, Jie 1,2
发表期刊	PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
ISSN	1572-1000
	2022-12-01
卷号	40 页码:3
通讯作者	Liu, Gang(gangliu.cmitm@xmu.edu) ; Hu, Zhenhua(zhenhua.hu@ia.ac) ; Tian, Jie(tian@ieee.org)
摘要	Precise resection of hepatic carcinoma (HCC) remains challenging for cirrhotic patients. Cirrhosis not only effects intraoperative palpation, but can also cause severe false-positive problems to indocyanine green (ICG) fluores-cence imaging. Herein, we report the application of a nano-scale probe IgG-IRDye800CW to achieve precise HCC resection from cirrhotic liver. A 66-year-old male patient with liver cancer received intravenous injection of IgG-IRDye800CW (10 mg) 6 days prior to surgery, and none adverse effects were observed. During the operation, the HCC lesion in the right liver lobe was specifically detected on the near-infrared window II (NIR-II) fluorescence images. The high-contrast NIR-II fluorescence delineated a clear margin to improve surgical precision. These clinical observations showed high safety and feasibility of applying IgG-IRDye800CW NIR-II fluorescence im-aging to guide hepatic surgery and minimize hepatic function damage.
关键词	NIR-II fluorescence imaging Hepatic carcinoma (HCC) Cirrhosis Image-guided surgery Nano probe
DOI	10.1016/j.pdpdt.2022.103098
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81930048] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81801864] ; National Natural Science Foundation of China (NSFC)[82102236] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; CAS Youth Interdisciplinary Team[JCTD-2021-08] ; Beijing Natural Science Foundation[JQ19027] ; China Postdoctoral Science Foundation[2022T150037] ; China Postdoctoral Science Foundation[2021M690007] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[HLHPTP201703] ; innovative research team of high-level local universities in Shanghai
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences ; CAS Youth Interdisciplinary Team ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation ; Zhuhai High-level Health Personnel Team Project (Zhuhai) ; innovative research team of high-level local universities in Shanghai
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000860474600007
出版者	ELSEVIER
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/50410
专题	中国科学院分子影像重点实验室
通讯作者	Liu, Gang; Hu, Zhenhua; Tian, Jie
作者单位	1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China 3.Southwest Med Univ, Dept Gen Surg Hepatobiliary Surg, Affiliated Hosp, Luzhou, Peoples R China 4.Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang, Zeyu,Fang, Cheng,Zhang, Yang,et al. NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2022,40:3.
APA	Zhang, Zeyu.,Fang, Cheng.,Zhang, Yang.,Su, Song.,Li, Bo.,...&Tian, Jie.(2022).NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,40,3.
MLA	Zhang, Zeyu,et al."NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 40(2022):3.