CASIA OpenIR  > 中国科学院分子影像重点实验室
NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient
Zhang, Zeyu1,2; Fang, Cheng3; Zhang, Yang4; Su, Song3; Li, Bo3; Liu, Gang4; Hu, Zhenhua2,5; Tian, Jie1,2
Source PublicationPHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
ISSN1572-1000
2022-12-01
Volume40Pages:3
Corresponding AuthorLiu, Gang(gangliu.cmitm@xmu.edu) ; Hu, Zhenhua(zhenhua.hu@ia.ac) ; Tian, Jie(tian@ieee.org)
AbstractPrecise resection of hepatic carcinoma (HCC) remains challenging for cirrhotic patients. Cirrhosis not only effects intraoperative palpation, but can also cause severe false-positive problems to indocyanine green (ICG) fluores-cence imaging. Herein, we report the application of a nano-scale probe IgG-IRDye800CW to achieve precise HCC resection from cirrhotic liver. A 66-year-old male patient with liver cancer received intravenous injection of IgG-IRDye800CW (10 mg) 6 days prior to surgery, and none adverse effects were observed. During the operation, the HCC lesion in the right liver lobe was specifically detected on the near-infrared window II (NIR-II) fluorescence images. The high-contrast NIR-II fluorescence delineated a clear margin to improve surgical precision. These clinical observations showed high safety and feasibility of applying IgG-IRDye800CW NIR-II fluorescence im-aging to guide hepatic surgery and minimize hepatic function damage.
KeywordNIR-II fluorescence imaging Hepatic carcinoma (HCC) Cirrhosis Image-guided surgery Nano probe
DOI10.1016/j.pdpdt.2022.103098
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81930048] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81801864] ; National Natural Science Foundation of China (NSFC)[82102236] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; CAS Youth Interdisciplinary Team[JCTD-2021-08] ; Beijing Natural Science Foundation[JQ19027] ; China Postdoctoral Science Foundation[2022T150037] ; China Postdoctoral Science Foundation[2021M690007] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[HLHPTP201703] ; innovative research team of high-level local universities in Shanghai
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences ; CAS Youth Interdisciplinary Team ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation ; Zhuhai High-level Health Personnel Team Project (Zhuhai) ; innovative research team of high-level local universities in Shanghai
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000860474600007
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/50410
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiu, Gang; Hu, Zhenhua; Tian, Jie
Affiliation1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Southwest Med Univ, Dept Gen Surg Hepatobiliary Surg, Affiliated Hosp, Luzhou, Peoples R China
4.Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen, Peoples R China
5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Zeyu,Fang, Cheng,Zhang, Yang,et al. NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2022,40:3.
APA Zhang, Zeyu.,Fang, Cheng.,Zhang, Yang.,Su, Song.,Li, Bo.,...&Tian, Jie.(2022).NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,40,3.
MLA Zhang, Zeyu,et al."NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 40(2022):3.
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