Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient | |
Zhang, Zeyu1,2 ; Fang, Cheng3; Zhang, Yang4; Su, Song3; Li, Bo3; Liu, Gang4; Hu, Zhenhua2,5; Tian, Jie1,2
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| Source Publication | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
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| ISSN | 1572-1000 |
| 2022-12-01 | |
| Volume | 40Pages:3 |
| Corresponding Author | Liu, Gang(gangliu.cmitm@xmu.edu) ; Hu, Zhenhua(zhenhua.hu@ia.ac) ; Tian, Jie(tian@ieee.org) |
| Abstract | Precise resection of hepatic carcinoma (HCC) remains challenging for cirrhotic patients. Cirrhosis not only effects intraoperative palpation, but can also cause severe false-positive problems to indocyanine green (ICG) fluores-cence imaging. Herein, we report the application of a nano-scale probe IgG-IRDye800CW to achieve precise HCC resection from cirrhotic liver. A 66-year-old male patient with liver cancer received intravenous injection of IgG-IRDye800CW (10 mg) 6 days prior to surgery, and none adverse effects were observed. During the operation, the HCC lesion in the right liver lobe was specifically detected on the near-infrared window II (NIR-II) fluorescence images. The high-contrast NIR-II fluorescence delineated a clear margin to improve surgical precision. These clinical observations showed high safety and feasibility of applying IgG-IRDye800CW NIR-II fluorescence im-aging to guide hepatic surgery and minimize hepatic function damage. |
| Keyword | NIR-II fluorescence imaging Hepatic carcinoma (HCC) Cirrhosis Image-guided surgery Nano probe |
| DOI | 10.1016/j.pdpdt.2022.103098 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81930048] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81801864] ; National Natural Science Foundation of China (NSFC)[82102236] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; CAS Youth Interdisciplinary Team[JCTD-2021-08] ; Beijing Natural Science Foundation[JQ19027] ; China Postdoctoral Science Foundation[2022T150037] ; China Postdoctoral Science Foundation[2021M690007] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[HLHPTP201703] ; innovative research team of high-level local universities in Shanghai |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences ; CAS Youth Interdisciplinary Team ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation ; Zhuhai High-level Health Personnel Team Project (Zhuhai) ; innovative research team of high-level local universities in Shanghai |
| WOS Research Area | Oncology |
| WOS Subject | Oncology |
| WOS ID | WOS:000860474600007 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/50410 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Liu, Gang; Hu, Zhenhua; Tian, Jie |
| Affiliation | 1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China 3.Southwest Med Univ, Dept Gen Surg Hepatobiliary Surg, Affiliated Hosp, Luzhou, Peoples R China 4.Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China |
| First Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Zhang, Zeyu,Fang, Cheng,Zhang, Yang,et al. NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2022,40:3. |
| APA | Zhang, Zeyu.,Fang, Cheng.,Zhang, Yang.,Su, Song.,Li, Bo.,...&Tian, Jie.(2022).NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,40,3. |
| MLA | Zhang, Zeyu,et al."NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 40(2022):3. |
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