Knowledge Commons of Institute of Automation,CAS
A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents | |
Qu, Xue-Tong1,2,3; Wu, Jin-Ni1,2,3; Wen, Yunqing1; Chen, Long1; Lv, Shi-Lei4; Liu, Li4; Zhan, Li-Jie1; Liu, Tian-Yi5; He, Hua5; Liu, Yu4; Xu, Chun1,2,3 | |
发表期刊 | NEUROSCIENCE BULLETIN |
ISSN | 1673-7067 |
2022-11-08 | |
页码 | 14 |
通讯作者 | He, Hua(hehua1624@smmu.edu.cn) ; Liu, Yu(yu.liu@ia.ac.cn) ; Xu, Chun(chun.xu@ion.ac.cn) |
摘要 | Animal survival necessitates adaptive behaviors in volatile environmental contexts. Virtual reality (VR) technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental context by simulating the real world with maximized control of contextual elements. Yet current VR tools for rodents have limited flexibility and performance (e.g., frame rate) for context-dependent cognitive research. Here, we describe a high-performance VR platform with which to study contextual behaviors immersed in editable virtual contexts. This platform was assembled from modular hardware and custom-written software with flexibility and upgradability. Using this platform, we trained mice to perform context-dependent cognitive tasks with rules ranging from discrimination to delayed-sample-to-match while recording from thousands of hippocampal place cells. By precise manipulations of context elements, we found that the context recognition was intact with partial context elements, but impaired by exchanges of context elements. Collectively, our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording. |
关键词 | Virtual reality Spatial context Contextual behavior Hippocampus Place cell Learning and memory Ca2+ imaging |
DOI | 10.1007/s12264-022-00964-0 |
关键词[WOS] | HIPPOCAMPAL PLACE CELLS ; NEUROSCIENCE ; CIRCUITS |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Science and Technology Innovation[2022ZD0205000] ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32010105] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS01010100] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Natural Science Foundation of China[31771180] ; National Natural Science Foundation of China[91732106] ; International Collaborative Project of the Shanghai Science and Technology Committee[201978677] ; Lingang Lab[LG202104-01-08] |
项目资助者 | National Science and Technology Innovation ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China ; International Collaborative Project of the Shanghai Science and Technology Committee ; Lingang Lab |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000880355400001 |
出版者 | SPRINGER |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/50706 |
专题 | 多模态人工智能系统全国重点实验室_脑机融合与认知评估 |
通讯作者 | He, Hua; Liu, Yu; Xu, Chun |
作者单位 | 1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 5.Navy Mil Med Univ, Dept Neurosurg, Affiliated Hosp 3, Shanghai 200438, Peoples R China |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Qu, Xue-Tong,Wu, Jin-Ni,Wen, Yunqing,et al. A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents[J]. NEUROSCIENCE BULLETIN,2022:14. |
APA | Qu, Xue-Tong.,Wu, Jin-Ni.,Wen, Yunqing.,Chen, Long.,Lv, Shi-Lei.,...&Xu, Chun.(2022).A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents.NEUROSCIENCE BULLETIN,14. |
MLA | Qu, Xue-Tong,et al."A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents".NEUROSCIENCE BULLETIN (2022):14. |
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