| A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents | |
Qu, Xue-Tong1,2,3; Wu, Jin-Ni1,2,3; Wen, Yunqing1; Chen, Long1 ; Lv, Shi-Lei4; Liu, Li4; Zhan, Li-Jie1; Liu, Tian-Yi5; He, Hua5; Liu, Yu4; Xu, Chun1,2,3
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| Source Publication | NEUROSCIENCE BULLETIN
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| ISSN | 1673-7067 |
| 2022-11-08 | |
| Pages | 14 |
| Corresponding Author | He, Hua(hehua1624@smmu.edu.cn) ; Liu, Yu(yu.liu@ia.ac.cn) ; Xu, Chun(chun.xu@ion.ac.cn) |
| Abstract | Animal survival necessitates adaptive behaviors in volatile environmental contexts. Virtual reality (VR) technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental context by simulating the real world with maximized control of contextual elements. Yet current VR tools for rodents have limited flexibility and performance (e.g., frame rate) for context-dependent cognitive research. Here, we describe a high-performance VR platform with which to study contextual behaviors immersed in editable virtual contexts. This platform was assembled from modular hardware and custom-written software with flexibility and upgradability. Using this platform, we trained mice to perform context-dependent cognitive tasks with rules ranging from discrimination to delayed-sample-to-match while recording from thousands of hippocampal place cells. By precise manipulations of context elements, we found that the context recognition was intact with partial context elements, but impaired by exchanges of context elements. Collectively, our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording. |
| Keyword | Virtual reality Spatial context Contextual behavior Hippocampus Place cell Learning and memory Ca2+ imaging |
| DOI | 10.1007/s12264-022-00964-0 |
| WOS Keyword | HIPPOCAMPAL PLACE CELLS ; NEUROSCIENCE ; CIRCUITS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Science and Technology Innovation[2022ZD0205000] ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32010105] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS01010100] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Natural Science Foundation of China[31771180] ; National Natural Science Foundation of China[91732106] ; International Collaborative Project of the Shanghai Science and Technology Committee[201978677] ; Lingang Lab[LG202104-01-08] |
| Funding Organization | National Science and Technology Innovation ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China ; International Collaborative Project of the Shanghai Science and Technology Committee ; Lingang Lab |
| WOS Research Area | Neurosciences & Neurology |
| WOS Subject | Neurosciences |
| WOS ID | WOS:000880355400001 |
| Publisher | SPRINGER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/50706 |
| Collection | 综合信息系统研究中心_脑机融合与认知评估 |
| Corresponding Author | He, Hua; Liu, Yu; Xu, Chun |
| Affiliation | 1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 5.Navy Mil Med Univ, Dept Neurosurg, Affiliated Hosp 3, Shanghai 200438, Peoples R China |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Qu, Xue-Tong,Wu, Jin-Ni,Wen, Yunqing,et al. A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents[J]. NEUROSCIENCE BULLETIN,2022:14. |
| APA | Qu, Xue-Tong.,Wu, Jin-Ni.,Wen, Yunqing.,Chen, Long.,Lv, Shi-Lei.,...&Xu, Chun.(2022).A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents.NEUROSCIENCE BULLETIN,14. |
| MLA | Qu, Xue-Tong,et al."A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents".NEUROSCIENCE BULLETIN (2022):14. |
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