A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents

doi:10.1007/s12264-022-00964-0

CASIA OpenIR > 多模态人工智能系统全国重点实验室 > 脑机融合与认知评估

	A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents
	Qu, Xue-Tong 1,2,3; Wu, Jin-Ni 1,2,3; Wen, Yunqing 1; Chen, Long1 ; Lv, Shi-Lei 4; Liu, Li 4; Zhan, Li-Jie 1; Liu, Tian-Yi 5; He, Hua 5; Liu, Yu4 ; Xu, Chun 1,2,3
发表期刊	NEUROSCIENCE BULLETIN
ISSN	1673-7067
	2022-11-08
页码	14
通讯作者	He, Hua(hehua1624@smmu.edu.cn) ; Liu, Yu(yu.liu@ia.ac.cn) ; Xu, Chun(chun.xu@ion.ac.cn)
摘要	Animal survival necessitates adaptive behaviors in volatile environmental contexts. Virtual reality (VR) technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental context by simulating the real world with maximized control of contextual elements. Yet current VR tools for rodents have limited flexibility and performance (e.g., frame rate) for context-dependent cognitive research. Here, we describe a high-performance VR platform with which to study contextual behaviors immersed in editable virtual contexts. This platform was assembled from modular hardware and custom-written software with flexibility and upgradability. Using this platform, we trained mice to perform context-dependent cognitive tasks with rules ranging from discrimination to delayed-sample-to-match while recording from thousands of hippocampal place cells. By precise manipulations of context elements, we found that the context recognition was intact with partial context elements, but impaired by exchanges of context elements. Collectively, our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording.
关键词	Virtual reality Spatial context Contextual behavior Hippocampus Place cell Learning and memory Ca2+ imaging
DOI	10.1007/s12264-022-00964-0
关键词[WOS]	HIPPOCAMPAL PLACE CELLS ; NEUROSCIENCE ; CIRCUITS
收录类别	SCI
语种	英语
资助项目	National Science and Technology Innovation[2022ZD0205000] ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32010105] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS01010100] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Natural Science Foundation of China[31771180] ; National Natural Science Foundation of China[91732106] ; International Collaborative Project of the Shanghai Science and Technology Committee[201978677] ; Lingang Lab[LG202104-01-08]
项目资助者	National Science and Technology Innovation ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China ; International Collaborative Project of the Shanghai Science and Technology Committee ; Lingang Lab
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000880355400001
出版者	SPRINGER
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/50706
专题	多模态人工智能系统全国重点实验室_脑机融合与认知评估
通讯作者	He, Hua; Liu, Yu; Xu, Chun
作者单位	1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 5.Navy Mil Med Univ, Dept Neurosurg, Affiliated Hosp 3, Shanghai 200438, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Qu, Xue-Tong,Wu, Jin-Ni,Wen, Yunqing,et al. A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents[J]. NEUROSCIENCE BULLETIN,2022:14.
APA	Qu, Xue-Tong.,Wu, Jin-Ni.,Wen, Yunqing.,Chen, Long.,Lv, Shi-Lei.,...&Xu, Chun.(2022).A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents.NEUROSCIENCE BULLETIN,14.
MLA	Qu, Xue-Tong,et al."A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents".NEUROSCIENCE BULLETIN (2022):14.